SynthesisPediatric nephrology (Berlin, Germany)2018
Hyperammonemia associated with distal renal tubular acidosis or urinary tract infection: a systematic review.
Synthesis in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Renally Generated Ammonia as a Cause of Hyperammonaemic Non-Hepatic Encephalopathy.Nephrology (Carlton, Vic.) · 2026Article
- Article
- Hypercapnia-Induced Noncirrhotic Hyperammonemia (HIH): Unveiling an Unrecognized Association.Cureus · 2025Article
- Hyperammonemic encephalopathy requiring hemodialysis in a child with distal renal tubular acidosis.Journal of nephrology · 2025Article
- Encrusted pyelitis and hyperammonemia due to Corynebacterium urealyticum in a kidney transplant recipient.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2025Article
- IgD lambda multiple myeloma causing hyperammonaemia with possibly reduced ammonium excretion.BMJ case reports · 2022Article
- Molecular Aspects of Distal Kidney Tubular Acidosis in Children, Its Long-Term Outcome, and Relationship with Hyperammonemia.Turkish archives of pediatrics · 2022Article
- A novel cause of emergent hyperammonemia:Molecular genetics and metabolism reports · 2021Article
- Renal Tubular Acidosis and Management Strategies: A Narrative Review.Advances in therapy · 2021Review
- Prognosis of Patients with Sepsis and Non-Hepatic Hyperammonemia: A Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Hyperammonemia Post Lung Transplantation: A Review.Clinical medicine insights. Circulatory, respiratory and pulmonary medicine · 2020Review
- Impaired consciousness, hypokalaemia and renal tubular acidosis in sustained Nurofen Plus abuse.BMJ case reports · 2019Article
- Hyperammonemia and lactic acidosis in adults: Differential diagnoses with a focus on inborn errors of metabolism.Reviews in endocrine & metabolic disorders · 2018Review
- Improving outcomes for patients with distal renal tubular acidosis: recent advances and challenges ahead.Pediatric health, medicine and therapeutics · 2018Review
- The Story of Ammonia in Liver Disease: An Unraveling Continuum.Journal of clinical and experimental hepatologyReview
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperammonemia usually results from an inborn error of metabolism or from an advanced liver disease. Individual case reports suggest that both distal renal tubular acidosis and urinary tract infection may also result in hyperammonemia.
methodsA systematic review of the literature on hyperammonemia secondary to distal renal tubular acidosis and urinary tract infection was conducted.
resultsWe identified 39 reports on distal renal tubular acidosis or urinary tract infections in association with hyperammonemia published between 1980 and 2017. Hyperammonemia was detected in 13 children with distal renal tubular acidosis and in one adult patient with distal renal tubular acidosis secondary to primary hyperparathyroidism. In these patients a negative relationship was observed between circulating ammonia and bicarbonate levels (P < 0.05). In 31 patients (19 children, 12 adults), an acute urinary tract infection was complicated by acute hyperammonemia and symptoms and signs of acute neuronal dysfunction, such as an altered level of consciousness, convulsions and asterixis, often associated with signs of brain edema, such as anorexia and vomiting. Urea-splitting bacteria were isolated in 28 of the 31 cases. The urinary tract was anatomically or functionally abnormal in 30 of these patients.
conclusionsThis study reveals that both altered distal renal tubular acidification and urinary tract infection may be associated with relevant hyperammonemia in both children and adults.
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