ArticleEuropean radiology2018
Conventional and synthetic MRI in multiple sclerosis: a comparative study.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Cartesian MPnRAGE for Efficient Simultaneous Multi-Contrast and Quantitative Relaxometry Imaging.Magnetic resonance in medicine · 2026Article
- Mapping heterogeneous region- and tissue-specific brain ageing patterns using quantitative MRI.Brain communications · 2026Article
- Technical aspects and clinical applications of synthetic MRI: a scoping review.Diagnosis (Berlin, Germany) · 2025Article
- Synthetic MR: Clinical applications in neuroradiology.Neuroradiology · 2025Review
- Comparison of Syn T2-FLAIR and Syn DIR with conventional T2-FLAIR in displaying white matter hyperintensities in migraine patients.Neuroradiology · 2025Article
- Lesion assessment in multiple sclerosis: a comparison between synthetic and conventional fluid-attenuated inversion recovery imaging.Frontiers in neurology · 2025Article
- Predicting the status of lymphovascular space invasion using quantitative parameters from synthetic MRI in cervical squamous cell carcinoma without lymphatic metastasis.Frontiers in oncology · 2024Article
- Quantitative evaluation of risk factors for low back pain in young patients using synthetic magnetic resonance imaging and proton density fat fraction analyses.Therapeutic advances in chronic disease · 2024Article
- Article
- Assessment of 2D conventional and synthetic MRI in multiple sclerosis.Neuroradiology · 2022Article
- Synthetic MRI in children with tuberous sclerosis complex.Insights into imaging · 2022Article
- Synthetic MRI in the detection and quantitative evaluation of sacroiliac joint lesions in axial spondyloarthritis.Frontiers in immunology · 2022Article
- Magnetic resonance fingerprinting for preoperative differentiation between gonadotroph and non-gonadotroph pituitary macroadenomas.European radiology · 2021Article
- Synthetic MRI in Neurofibromatosis Type 1.AJNR. American journal of neuroradiology · 2021Article
- Validity of SyMRI for Assessment of the Neonatal Brain.Clinical neuroradiology · 2021Article
- 3D Quantitative Synthetic MRI in the Evaluation of Multiple Sclerosis Lesions.AJNR. American journal of neuroradiology · 2021Article
- The Effect of Intraventricular Hemorrhage on Brain Development in Premature Infants: A Synthetic MRI Study.Frontiers in neurology · 2021Article
- Comparison between synthetic and conventional magnetic resonance imaging in patients with multiple sclerosis and controls.Magma (New York, N.Y.) · 2020Article
- Follow-up MRI in multiple sclerosis patients: automated co-registration and lesion color-coding improves diagnostic accuracy and reduces reading time.European radiology · 2019Article
- Evaluating Tissue Contrast and Detecting White Matter Injury in the Infant Brain: A Comparison Study of Synthetic Phase-Sensitive Inversion Recovery.AJNR. American journal of neuroradiology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare the assessment of patients with multiple sclerosis (MS) using synthetic and conventional MRI. MATERIALS AND
methodsSynthetic and conventional axial images were prospectively acquired for 52 patients with diagnosed MS. Quantitative MRI (qMRI) was used for measuring proton density and relaxation times (T1, T2) and then, based on these parameters, synthetic T1W, T2W and FLAIR images were calculated. Image stacks were reviewed blindly, independently and in random order by two radiologists. The number and location for all lesions were documented and categorised. A combined report of lesion load and presence of contrast-enhancing lesions was compiled for each patient. Agreement was evaluated using kappa statistic.
resultsThere was no significant difference in lesion detection using synthetic and conventional MRI in any anatomical region or for any of the three image types. Inter- and intra-observer agreements were mainly higher (p < 0.05) using conventional images but there was no significant difference in any specific region or for any image type. There was no significant difference in the outcome of the combined reports.
conclusionSynthetic MR images show potential to be used in the assessment of MS dissemination in space (DIS) despite a slightly lower inter- and intra-observer agreement compared to conventional MRI. KEY POINTS: • Synthetic MR images may potentially be useful in the assessment of MS. • Examination times may be shortened. • Inter- and intra-observer agreement is generally higher using conventional MRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.