Evidence map›Paper›PMID 29134312›Full record

ArticleWorld journal of surgery2018

Refining the Definitions of Biochemical and Clinical Cure for Primary Aldosteronism Using the Primary Aldosteronism Surgical Outcome (PASO) Classification System.

B S Miller, A F Turcu, A T Nanba, D T Hughes, M S Cohen, P G Gauger, R J Auchus

Abstract read
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In one paragraph

Article in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. AVS-referenced diagnostic performance ofFrontiers in endocrinology · 2026
    Pooled it
  2. Pooled it
  3. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Guideline
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Journal of clinical & translational endocrinology · 2025
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Screening Rate for Primary Aldosteronism Among Patients With Apparent Treatment-Resistant Hypertension: Retrospective Analysis of Current Practice.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Article
  17. Review
  18. Article
  19. Article
  20. Long-term impact of spironolactone compliance on microalbuminuria in patients with primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

B S MillerDivision of Endocrine Surgery, Section of General Surgery, Department of Surgery, University of Michigan, 2920 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA. barbram@med.umich.edu.
A F TurcuDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
A T NanbaDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.
D T HughesDivision of Endocrine Surgery, Section of General Surgery, Department of Surgery, University of Michigan, 2920 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.
M S CohenDivision of Endocrine Surgery, Section of General Surgery, Department of Surgery, University of Michigan, 2920 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.
P G GaugerDivision of Endocrine Surgery, Section of General Surgery, Department of Surgery, University of Michigan, 2920 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.
R J AuchusDivision of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDetermination of outcomes after adrenalectomy for primary aldosteronism (PA) is limited by the lack of standardized definitions of cure. The Primary Aldosteronism Surgical Outcomes (PASO) group recently established new consensus definitions for biochemical and clinical cure of PA. We hypothesize that utilization of PASO definitions will better stratify patient outcomes after surgery compared to original and current criteria utilized to document cure. MATERIALS AND

methodsPatients undergoing adrenalectomy for PA from 1996 to 2016 were studied. Clinical data were reviewed. Three different sets of criteria (original, current, and PASO) were evaluated for differences in documentation of cure. Demographic data were reported as median (range). Comparisons were made using the Mann-Whitney U test; p < 0.05 is significant.

resultsA total of 314 patients with PA were identified. Ninety patients (60 males) elected to proceed with surgery. In Group 1 (35 patients), 30 patients had clinical follow-up and 29 (97%) were cured using original criteria. In Group 2 (55 patients), cure was recorded in 98% when original criteria for cure were applied, 89% cured applying current criteria, and 6% had complete biochemical and clinical cure by PASO criteria. Aldosterone rose 3.6 ng/dL (0.1-34.8) in five patients during extended follow-up, with two patients changing from complete to partial or missing biochemical success.

conclusionSignificant heterogeneity exists in outcomes criteria utilized to document cure or clinical improvement after adrenalectomy for primary aldosteronism. Aldosterone levels change over time after adrenalectomy. PASO definitions of cure appear to allow for improved stratification of short- and long-term outcomes.

Indexed as

AdrenalectomyAdultAgedAldosteroneBiomarkersFemaleHumansHyperaldosteronismHypertensionMaleMiddle AgedReninRetrospective StudiesTreatment OutcomeAldosteroneBiomarkersRenin

Identifiers

PMID29134312

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.