Evidence map›Paper›PMID 29134108›Full record

ArticleNPJ biofilms and microbiomes2017

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection.

Wei Xu, Ana L Flores-Mireles, Zachary T Cusumano, Enzo Takagi, Scott J Hultgren, Michael G Caparon

Open access · goldAbstract read
In one paragraph

Article in NPJ biofilms and microbiomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. CAUTIon - not all UTIs are the same.Nature reviews. Urology · 2025
    Review
  5. Metabolic cross-talk promotes persistence ofbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  9. Article
  10. Article
  11. The Impact ofPathogens (Basel, Switzerland) · 2024
    Review
  12. Review
  13. Article
  14. The Role of Metabolomics and Microbiology in Urinary Tract Infection.International journal of molecular sciences · 2024
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wei XuDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110-1093 USA.
Ana L Flores-MirelesDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110-1093 USA.
Zachary T CusumanoDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110-1093 USA.
Enzo TakagiDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110-1093 USA.
Scott J HultgrenDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110-1093 USA.
Michael G CaparonDepartment of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, Saint Louis, MO 63110-1093 USA.
Washington University in St. Louis · US

Funding

pan-Genome of E.coli in the bladder and gut of women with recurrent UTIP50DK064540 · NIDDK · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J. · 2002 to 2017
$17.9M
MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
EBPA-FIBROGEN INTERACTION IN ENTEROCOCCUS FAECALIS CAUTIR01AI108749 · NIAID · WASHINGTON UNIVERSITY · PI CAPARON, MICHAEL G. · 2014 to 2017
$1.5M
Understanding the role of inflammation, fibrinogen and neutrophils in persistence of E. faecalis during CAUTIF32DK104516 · NIDDK · WASHINGTON UNIVERSITY · PI FLORES-MIRELES, ANA LIDIA · 2014 to 2017
$172k
NIAID NIH HHS R01 AI108749NIDDK NIH HHS F32 DK104516NIDDK NIH HHS P50 DK064540NIDDK NIH HHS R01 DK051406
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID29134108
PMCPMC5673934
OpenAlexW2766000565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.