Evidence map›Paper›PMID 29133981›Full record

ArticleInternational journal of nanomedicine2017

Electrostatic interactions between polyglutamic acid and polylysine yields stable polyion complex micelles for deoxypodophyllotoxin delivery.

Yutong Wang, Liping Huang, Yan Shen, Lidan Tang, Runing Sun, Di Shi, Thomas J Webster, Jiasheng Tu, Chunmeng Sun

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yutong Wang *Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University.
Liping Huang *Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University.
Yan Shen *Center for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University.
Lidan TangCenter for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University.
Runing SunCenter for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University.
Di ShiDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.
Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, Boston, MA, USA.
Jiasheng TuCenter for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University.
Chunmeng SunCenter for Research Development and Evaluation of Pharmaceutical Excipients and Generic Drugs, China Pharmaceutical University.
China Pharmaceutical University · CNState Key Laboratory of Natural MedicineNanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To achieve enhanced physical stability of poly(ethylene glycol)-poly(d,l-lactide) polymeric micelles (PEG-PDLLA PMs), a mixture of methoxy PEG-PDLLA-polyglutamate (mPEG-PDLLA-PLG) and mPEG-PDLLA-poly(l-lysine) (mPEG-PDLLA-PLL) copolymers was applied to self-assembled stable micelles with polyion-stabilized cores. Prior to micelle preparation, the synthetic copolymers were characterized by

Indexed as

AnimalsDrug CarriersDrug LiberationDrugs, Chinese HerbalHydrogen-Ion ConcentrationMagnetic Resonance SpectroscopyMaleMicellesMolecular WeightParticle SizePodophyllotoxinPolyestersPolyethylene GlycolsPolyglutamic AcidPolylysineProton Magnetic Resonance SpectroscopydeoxypodophyllotoxinDrug CarriersDrugs, Chinese Herbalmethoxy poly(ethylene glycol)-block-poly(lactic acid)MicellesPodophyllotoxinPolyestersPolyethylene GlycolsPolyglutamic AcidPolylysineelectrostatic interactionoligopeptidepharmacokineticspolyion complex micellesstability

Identifiers

PMID29133981
PMCPMC5669785
OpenAlexW2765208240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.