ArticleScientific reports2017
Triplex-quadruplex structural scaffold: a new binding structure of aptamer.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next-Generation Diagnostics and Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Biomolecule-Photosensitizer Conjugates: A Strategy to Enhance Selectivity and Therapeutic Efficacy in Photodynamic Therapy.Pharmaceuticals (Basel, Switzerland) · 2025Review
- A Non-G-Quadruplex Hemin Aptamer Forms a Better Peroxidase Mimicking DNAzyme.Chembiochem : a European journal of chemical biology · 2025Article
- Diversity of ribosomes at the level of rRNA variation associated with human health and disease.Cell genomics · 2024Article
- Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide.Nucleic acids research · 2023Article
- Structural Optimization and Interaction Study of a DNA Aptamer to L1 Cell Adhesion Molecule.International journal of molecular sciences · 2023Article
- Entropy-driven dynamic self-assembled DNA dendrimers for colorimetric detection of African swine fever virus.Analytical and bioanalytical chemistry · 2023Article
- Selection and Characterization of DNA Aptamers for Constructing Aptamer-AuNPs Colorimetric Method for Detection of AFM1.Foods (Basel, Switzerland) · 2022Article
- Unraveling the binding mode of a methamphetamine aptamer: A spectroscopic and calorimetric study.Biophysical journal · 2022Article
- Beyond G-Quadruplexes-The Effect of Junction with Additional Structural Motifs on Aptamers Properties.International journal of molecular sciences · 2021Review
- Recent Advances in Micro/Nanomaterial-Based Aptamer Selection Strategies.Molecules (Basel, Switzerland) · 2021Review
- Article
- Quadruplex-Duplex Junction: A High-Affinity Binding Site for Indoloquinoline Ligands.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Nanomaterial-based aptamer sensors for analysis of illicit drugs and evaluation of drugs consumption for wastewater-based epidemiology.Trends in analytical chemistry : TRAC · 2020Review
- An overview and future prospects on aptamers for food safety.Applied microbiology and biotechnology · 2020Review
- Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection.Frontiers in chemistry · 2020Review
- G-Quadruplex-Forming Aptamers-Characteristics, Applications, and Perspectives.Molecules (Basel, Switzerland) · 2019Review
- G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications.Molecules (Basel, Switzerland) · 2019Review
- Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells.Scientific reports · 2019Article
- Synthesis and surface characterization of new triplex polymer of Ag(I) and mixture nucleosides: cytidine and 8-bromoguanosine.Heliyon · 2019Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apart from the canonical Watson-Crick duplex, nucleic acids can often form other structures, e.g. G-quadruplex and triplex. These structures give nucleic acid additional functions besides coding for genetic information. Aptamers are one type of functional nucleic acids that bind to specific targets with high selectivity and affinity by folding into special tertiary structures. Despite the fact that numerous aptamers have been reported, only a few different types of aptamer structures are identified. Here we report a novel triplex-quadruplex hybrid scaffold formed by a codeine binding aptamer (CBA). CBA and its derivatives are G-rich DNA sequences. Codeine binding can induce the formation of a complex structure for this aptamer containing a G-quadruplex and a G·GC triplex, while codeine is located at the junction of the triplex and quadruplex. When split CBA into two moieties, codeine does not bind either moieties individually, but can bind them together by inducing the formation of the triplex-quadruplex scaffold. This structure formation induced by codeine binding is shown to inhibit polymerase reaction, which shows a potential application of the aptamer sequence in gene regulations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.