ArticleScientific reports2017
Nitric oxide mediated inhibition of antigen presentation from DCs to CD4
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 64 papers.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 91 citations in OpenAlex.
- Multi-Dimensional Flow Cytometry Analyses Reveal a Dichotomous Role for Nitric Oxide in Melanoma Patients Receiving Immunotherapy.Frontiers in immunology · 2020Trial
- Molecular Mechanisms and Immune Regulation in Prostate Cancer: A Review.International journal of molecular sciences · 2026Review
- Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide.Scientific reports · 2026Article
- The role of tumor metabolic reprogramming in acquired anti-PD-1/PD-L1 resistance.Translational lung cancer research · 2026Review
- Heterocellular crosstalk and architecture of the pancreatic tumour microenvironment.Nature reviews. Cancer · 2026Review
- S-nitrosylation of IRF7 induced by NOS1 expression in melanoma suppresses anti-tumor immunity.Cell death & disease · 2026Article
- Targeting innate immunity in cancer: mechanistic foundations, therapeutic vaccination, and clinical translation.Frontiers in immunology · 2026Review
- Gasotransmitters bridging tumor biology and immunity: from pathophysiological insights to therapeutic potential.Frontiers in immunology · 2026Review
- iNOS is a key mediator of anti-PD-1 melanoma therapy response.Frontiers in immunology · 2026Article
- Myeloid-derived suppressor cells in colorectal cancer: mechanisms of immunosuppression, therapy resistance and therapeutic targeting.Frontiers in cell and developmental biology · 2026Review
- Recent advances in the investigation of the regulatory network underlying reactive nitrogen species-mediated tumorigenesis: molecular mechanisms and targeted therapeutic strategies.Redox report : communications in free radical research · 2025Review
- Blocking Nitrosylation Induces Immunogenic Cell Death by Sensitizing NRAS-Mutant Melanoma to MEK Inhibitors.Cancer research · 2025Article
- Extracellular Vesicle-Based Strategies for Tumor Immunotherapy.Pharmaceutics · 2025Review
- The Recruitment and Immune Suppression Mechanisms of Myeloid-Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer.Cancer reports (Hoboken, N.J.) · 2025Review
- Therapeutic advantage of combinatorial chimeric antigen receptor T cell and chemotherapies.Pharmacological reviews · 2025Review
- Nitric oxide-based multi-synergistic nanomedicine: an emerging therapeutic for anticancer.Journal of nanobiotechnology · 2024Review
- Prostate Cancer: A Review of Genetics, Current Biomarkers and Personalised Treatments.Cancer reports (Hoboken, N.J.) · 2024Review
- In vitro immuno-prevention of nitration/dysfunction of myogenic stem cell activator HGF, towards developing a strategy for age-related muscle atrophy.Aging cell · 2024Article
- Current and future immunotherapeutic approaches in pancreatic cancer treatment.Journal of hematology & oncology · 2024Review
- Single-Cell RNA-Seq Analysis of Patient Myeloid-Derived Suppressor Cells and the Response to Inhibition of Bruton's Tyrosine Kinase.Molecular cancer research : MCR · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 3 institutions in 1 country.
Joseph MarkowitzMoffitt Cancer Center Department of Cutaneous Oncology, Tampa, United States. joseph.markowitz@moffitt.org.
Jiang WangComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Zach VangundyComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Jia YouComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Vedat YildizComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Lianbo YuComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Isaac P FooteMoffitt Cancer Center Department of Cutaneous Oncology, Tampa, United States.
Owen E BransonComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Andrew R StiffComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Taylor R BrooksComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Brandon BiesiadeckiDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, United States.
Thomas OlenckiDivision of Medical Oncology, The Ohio State University Wexner Medical Center, Columbus, United States.
Susheela TridandapaniComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Michael A FreitasComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Tracey PapenfussComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
Mitch A PhelpsComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States.
William E CarsonComprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, United States. william.carson@osumc.edu.
The Ohio State University Wexner Medical Center · USMoffitt Cancer Center · USThe Ohio State University · US
Funding
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5MTWO SIGNAL REQUIREMENT FOR NATURAL KILLER IMMUNITYP01CA095426 · NCI · OHIO STATE UNIVERSITY · PI CALIGIURI, MICHAEL A · 2002 to 2016
$29.6MTissue, Pathology and BioinformaticsP50CA168536 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI MULE, JAMES J. · 2013 to 2017
$8.5MTumor ImmunologyT32CA090223 · NCI · OHIO STATE UNIVERSITY · PI CARSON, WILLIAM E. · 2002 to 2023
$4.1MIntegrated Crosstalk of Thin Filament Post-translational ModificationsR01HL114940 · NHLBI · OHIO STATE UNIVERSITY · PI BIESIADECKI, BRANDON J · 2013 to 2021
$3.6MNCI NIH HHS P01 CA095426NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA168536NCI NIH HHS T32 CA090223NHLBI NIH HHS R01 HL114940
Abstract
Myeloid derived suppressor cells (MDSC) produce nitric oxide (NO) and inhibit dendritic cell (DC) immune responses in cancer. DCs present cancer cell antigens to CD4
Indexed as
AnimalsAntigen PresentationAntigens, NeoplasmCD4-Positive T-LymphocytesDendritic CellsHumansMelanoma, ExperimentalMiceMice, TransgenicMyeloid-Derived Suppressor CellsNitric OxideNitric Oxide DonorsPancreatic NeoplasmsSTAT1 Transcription FactorTandem Mass SpectrometryAntigens, NeoplasmNitric OxideNitric Oxide DonorsSTAT1 protein, humanSTAT1 Transcription Factor
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.