ArticleScientific reports2017
The food-borne pathogen Campylobacter jejuni responds to the bile salt deoxycholate with countermeasures to reactive oxygen species.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Fluorescein-based dyes are not valid reporters of oxidative stress in bacteria, and conclusions based on their use must be reconsidered.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- An invasive phenotype induced by relaxation of DNA supercoiling inMicrobiology (Reading, England) · 2025Article
- Selective depletion of Campylobacter jejuni via T6SS dependent functionality: an approach for improving chickens gut health.Gut pathogens · 2024Article
- Oral treatment of human gut microbiota associated IL-10Frontiers in microbiology · 2024Article
- Cryptic Prophages Contribution forMicroorganisms · 2022Article
- The bile salt deoxycholate inducesFrontiers in microbiology · 2022Article
- The cost of bacterial predation via type VI secretion system leads to predator extinction under environmental stress.iScience · 2021Article
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- A porcine ligated loop model reveals new insight into the host immune response againstGut microbes · 2020Article
- The Great ESKAPE: Exploring the Crossroads of Bile and Antibiotic Resistance in Bacterial Pathogens.Infection and immunity · 2020Review
- First record of a tandem-repeat region within the mitochondrial genome of Clonorchis sinensis using a long-read sequencing approach.PLoS neglected tropical diseases · 2020Article
- Proteome Profiling by Label-Free Mass Spectrometry Reveals Differentiated Response of Campylobacter jejuni 81-176 to Sublethal Concentrations of Bile Acids.Proteomics. Clinical applications · 2019Article
- Microbial metabolite deoxycholic acid shapes microbiota against Campylobacter jejuni chicken colonization.PloS one · 2019Article
- Article
- Avian Intestinal Mucus ModulatesFrontiers in microbiology · 2018Article
- The food-borne pathogen Campylobacter jejuni depends on the AddAB DNA repair system to defend against bile in the intestinal environment.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Bile plays an important role in digestion, absorption of fats, and the excretion of waste products, while concurrently providing a critical barrier against colonization by harmful bacteria. Previous studies have demonstrated that gut pathogens react to bile by adapting their protein synthesis. The ability of pathogens to respond to bile is remarkably complex and still incompletely understood. Here we show that Campylobacter jejuni, a leading bacterial cause of human diarrheal illness worldwide, responds to deoxycholate, a component of bile, by altering global gene transcription in a manner consistent with a strategy to mitigate exposure to reactive oxygen stress. More specifically, continuous growth of C. jejuni in deoxycholate was found to: 1) induce the production of reactive oxygen species (ROS); 2) decrease succinate dehydrogenase activity (complex II of the electron transport chain); 3) increase catalase activity that is involved in H
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