Evidence map›Paper›PMID 29133818›Full record

ArticleScientific reports2017

Searching for prostate cancer by fully automated magnetic resonance imaging classification: deep learning versus non-deep learning.

Xinggang Wang, Wei Yang, Jeffrey Weinreb, Juan Han, Qiubai Li, Xiangchuang Kong, Yongluan Yan, Zan Ke, Bo Luo, Tao Liu and 1 more

Open access · goldAbstract readComparative StudyValidation Study
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 197 citations in OpenAlex.

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  9. Artificial Intelligence in Dentistry: A Narrative Review of Diagnostic and Therapeutic Applications.Medical science monitor : international medical journal of experimental and clinical research · 2025
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Xinggang WangDepartment of Radiology, Tongji Hospital, Huazhong University of Science and Technology, Jiefang Road 1095, 430030, Wuhan, China.
Wei YangDepartment of Nutrition and Food Hygiene, MOE Key Lab of Environment, Hubei Key Laboratory of Food Nutrition and Safety, Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030, Wuhan, China.
Jeffrey WeinrebDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, 208042, Connecticut, USA.
Juan HanDepartment of Maternal and Child and Adolescent & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030, Wuhan, China.
Qiubai LiProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA.
Xiangchuang KongDepartment of Radiology, Union Hospital, Huazhong University of Science and Technology, Jiefang Road 1277, 430022, Wuhan, China.
Yongluan YanSchool of Electronics Information and Communications, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan, Hubei, 430074, China.
Zan KeDepartment of Radiology, Tongji Hospital, Huazhong University of Science and Technology, Jiefang Road 1095, 430030, Wuhan, China.
Bo LuoSchool of mechanical science and engineering, Huazhong University of Science and Technology, Luoyu Road 1037, 430074, Wuhan, China.
Tao LiuSchool of mechanical science and engineering, Huazhong University of Science and Technology, Luoyu Road 1037, 430074, Wuhan, China.
Liang WangDepartment of Radiology, Tongji Hospital, Huazhong University of Science and Technology, Jiefang Road 1095, 430030, Wuhan, China. wang6@tjh.tjmu.edu.cn.
Huazhong University of Science and Technology · CNBoston Children's Hospital · USUnion Hospital · CNYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PCa) is a major cause of death since ancient time documented in Egyptian Ptolemaic mummy imaging. PCa detection is critical to personalized medicine and varies considerably under an MRI scan. 172 patients with 2,602 morphologic images (axial 2D T2-weighted imaging) of the prostate were obtained. A deep learning with deep convolutional neural network (DCNN) and a non-deep learning with SIFT image feature and bag-of-word (BoW), a representative method for image recognition and analysis, were used to distinguish pathologically confirmed PCa patients from prostate benign conditions (BCs) patients with prostatitis or prostate benign hyperplasia (BPH). In fully automated detection of PCa patients, deep learning had a statistically higher area under the receiver operating characteristics curve (AUC) than non-deep learning (P = 0.0007 < 0.001). The AUCs were 0.84 (95% CI 0.78-0.89) for deep learning method and 0.70 (95% CI 0.63-0.77) for non-deep learning method, respectively. Our results suggest that deep learning with DCNN is superior to non-deep learning with SIFT image feature and BoW model for fully automated PCa patients differentiation from prostate BCs patients. Our deep learning method is extensible to image modalities such as MR imaging, CT and PET of other organs.

Indexed as

Deep LearningAgedAged, 80 and overDiagnosis, DifferentialHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedProstateProstatic HyperplasiaProstatic NeoplasmsProstatitisRetrospective StudiesROC Curve

Identifiers

PMID29133818
PMCPMC5684419
OpenAlexW2767969013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.