Evidence map›Paper›PMID 29133817›Full record

ArticleNature communications2017

Transgenic Cavendish bananas with resistance to Fusarium wilt tropical race 4.

James Dale, Anthony James, Jean-Yves Paul, Harjeet Khanna, Mark Smith, Santy Peraza-Echeverria, Fernando Garcia-Bastidas, Gert Kema, Peter Waterhouse, Kerrie Mengersen and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
37.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 288 citations in OpenAlex.

  1. Adaptive Responses of Tropical Crops: A Multi-Scale Omics Integrated Perspective.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  13. Chromosomal deletions in banana somaclonal variants reveal negative regulators of immunity underlyingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Banana breeding by genome design.Journal of integrative plant biology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

James DaleCentre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, 4001, Queensland, Australia. j.dale@qut.edu.au.
Anthony JamesCentre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, 4001, Queensland, Australia.
Jean-Yves PaulCentre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, 4001, Queensland, Australia.ORCID http://orcid.org/0000-0003-3246-2210
Harjeet KhannaCentre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, 4001, Queensland, Australia.ORCID http://orcid.org/0000-0001-6094-0924
Mark SmithDarwin Banana Farming Company, Lambells Lagoon, 0822, Northern Territory, Australia.
Santy Peraza-EcheverriaCentre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, 4001, Queensland, Australia.
Fernando Garcia-BastidasWageningen University and Research Centre, Plant Research International, Wageningen, 6700, The Netherlands.
Gert KemaWageningen University and Research Centre, Plant Research International, Wageningen, 6700, The Netherlands.
Peter WaterhouseCentre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, 4001, Queensland, Australia.
Kerrie MengersenScience and Engineering Faculty, Queensland University of Technology, Brisbane, 4001, Queensland, Australia.
Robert HardingCentre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, 4001, Queensland, Australia.
Queensland University of Technology · AUWageningen University & Research · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Banana (Musa spp.) is a staple food for more than 400 million people. Over 40% of world production and virtually all the export trade is based on Cavendish banana. However, Cavendish banana is under threat from a virulent fungus, Fusarium oxysporum f. sp. cubense tropical race 4 (TR4) for which no acceptable resistant replacement has been identified. Here we report the identification of transgenic Cavendish with resistance to TR4. In our 3-year field trial, two lines of transgenic Cavendish, one transformed with RGA2, a gene isolated from a TR4-resistant diploid banana, and the other with a nematode-derived gene, Ced9, remain disease free. Transgene expression in the RGA2 lines is strongly correlated with resistance. Endogenous RGA2 homologs are also present in Cavendish but are expressed tenfold lower than that in our most resistant transgenic line. The expression of these homologs can potentially be elevated through gene editing, to provide non-transgenic resistance.

Indexed as

Disease ResistanceAmino Acid SequenceDiploidyFusariumGene EditingGene Expression Regulation, PlantGenes, PlantMusaPlant DiseasesPlants, Genetically ModifiedSequence AlignmentVirulence

Identifiers

PMID29133817
PMCPMC5684404
OpenAlexW2767983380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.