Evidence map›Paper›PMID 29133802›Full record

ArticleNature communications2017

A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria.

Kelvin Caban, Michael Pavlov, Måns Ehrenberg, Ruben L Gonzalez

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. YfmR is a translation factor that prevents ribosome stalling and cell death in the absence of EF-P.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Transcription regulates ribosome hibernation.Molecular microbiology · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. The alarmones (p)ppGpp directly regulate translation initiation during entry into quiescence.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Kelvin CabanDepartment of Chemistry, Columbia University, 3000 Broadway, MC3126, New York, NY, 10027, USA.
Michael PavlovDepartment of Cell and Molecular Biology, BMC, Uppsala University, Husargatan 3, Uppsala, 751 24, Sweden.
Måns EhrenbergDepartment of Cell and Molecular Biology, BMC, Uppsala University, Husargatan 3, Uppsala, 751 24, Sweden.
Ruben L GonzalezDepartment of Chemistry, Columbia University, 3000 Broadway, MC3126, New York, NY, 10027, USA. rlg2118@columbia.edu.ORCID http://orcid.org/0000-0002-1344-5581
Columbia University · USUppsala University · SE

Funding

The Structural Dynamics of Translation InitiationR01GM084288 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GONZALEZ, RUBEN L · 2009 to 2022
$4.4M
NIGMS NIH HHS R01 GM084288
6 · The paper itself

Abstract

Initiation factor (IF) 2 controls the fidelity of translation initiation by selectively increasing the rate of 50S ribosomal subunit joining to 30S initiation complexes (ICs) that carry an N-formyl-methionyl-tRNA (fMet-tRNA

Indexed as

Allosteric RegulationEscherichia coliEscherichia coli ProteinsFluorescence Resonance Energy TransferGuanosine TriphosphateKineticsModels, BiologicalMutationProkaryotic Initiation Factor-2Protein BiosynthesisProtein ConformationProtein DomainsRibosome Subunits, Large, BacterialRibosome Subunits, Small, BacterialRNA, Transfer, MetSingle Molecule ImagingEscherichia coli ProteinsGuanosine TriphosphateProkaryotic Initiation Factor-2RNA, Transfer, MettRNA, formylmethionine-

Identifiers

PMID29133802
PMCPMC5684235
OpenAlexW2767810627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.