ArticleNature communications2017
Heterogeneity in the Drosophila gustatory receptor complexes that detect aversive compounds.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- A Molecular and Cellular Mechanism for Bitter Taste in the mosquitobioRxiv : the preprint server for biology · 2026Article
- Increased heterozygosity and balancing selection in isofemale generations of Anopheles stephensi under laboratory conditions.BMC genomics · 2025Article
- Bitter Sensing ProtectsThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cholesterol taste avoidance ineLife · 2025Article
- Molecular evolution of gustatory receptors in the Anopheles gambiae complex.BMC ecology and evolution · 2025Article
- Amino acids activate parallel chemosensory pathways in Drosophila.Chemical senses · 2025Article
- A structural perspective on insect gustatory receptors.Chemical senses · 2025Review
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Molecular Functions and Physiological Roles of Gustatory Receptors of the SilkwormInternational journal of molecular sciences · 2024Review
- Molecular and cellular basis of sodium sensing iniScience · 2024Article
- Avoiding alkaline taste through ionotropic receptors.iScience · 2024Article
- Taste evolution in an herbivorous drosophilid.bioRxiv : the preprint server for biology · 2024Article
- Mechanisms of gas sensing by internal sensory neurons inbioRxiv : the preprint server for biology · 2024Article
- Article
- The power of Drosophila genetics in studying insect toxicology and chemical ecology.Crop health · 2023Review
- Molecular sensors in the taste system of Drosophila.Genes & genomics · 2023Review
- Taste coding of heavy metal ion-induced avoidance iniScience · 2023Article
- RNA Taste Is Conserved in Dipteran Insects.The Journal of nutrition · 2023Article
- Alkaline taste sensation through the alkaliphile chloride channel in Drosophila.Nature metabolism · 2023Article
- Taste adaptations associated with host specialization in the specialist Drosophila sechellia.The Journal of experimental biology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animals must detect aversive compounds to survive. Bitter taste neurons express heterogeneous combinations of bitter receptors that diversify their response profiles, but this remains poorly understood. Here we describe groups of taste neurons in Drosophila that detect the same bitter compounds using unique combinations of gustatory receptors (GRs). These distinct complexes also confer responsiveness to non-overlapping sets of additional compounds. While either GR32a/GR59c/GR66a or GR22e/GR32a/GR66a heteromultimers are sufficient for lobeline, berberine, and denatonium detection, only GR22e/GR32a/GR66a responds to strychnine. Thus, despite minimal sequence-similarity, Gr22e and Gr59c show considerable but incomplete functional overlap. Since the gain- or loss-of-function of Gr22e or Gr59c alters bitter taste response profiles, we conclude a taste neuron's specific combination of Grs determines its response profile. We suspect the heterogeneity of Gr expression in Drosophila taste neurons diversifies bitter compound detection, improving animal fitness under changing environmental conditions that present a variety of aversive compounds.
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