Evidence map›Paper›PMID 29133622›Full record

ArticleMolecular cancer therapeutics2018

Ceritinib Enhances the Efficacy of Trametinib in

Daniel Verduzco, Brent M Kuenzi, Fumi Kinose, Vernon K Sondak, Zeynep Eroglu, Uwe Rix, Keiran S M Smalley

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
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  10. Overcoming resistance to BRAFNPJ precision oncology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Daniel VerduzcoThe Department of Tumor Biology, The Moffitt Cancer Center and Research Institute, Tampa, Florida.
Brent M KuenziThe Department of Drug Discovery, The Moffitt Cancer Center and Research Institute, Tampa, Florida.
Fumi KinoseThe Department of Drug Discovery, The Moffitt Cancer Center and Research Institute, Tampa, Florida.
Vernon K SondakThe Department of Cutaneous Oncology, The Moffitt Cancer Center and Research Institute, Tampa, Florida.
Zeynep ErogluThe Department of Cutaneous Oncology, The Moffitt Cancer Center and Research Institute, Tampa, Florida.
Uwe RixThe Department of Drug Discovery, The Moffitt Cancer Center and Research Institute, Tampa, Florida.
Keiran S M SmalleyThe Department of Tumor Biology, The Moffitt Cancer Center and Research Institute, Tampa, Florida. keiran.smalley@moffitt.org.
Moffitt Cancer Center · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5M
Tissue, Pathology and BioinformaticsP50CA168536 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI MULE, JAMES J. · 2013 to 2017
$8.5M
Harnessing beneficial off-target effects of kinase inhibitors in lung cancerR01CA181746 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RIX, UWE · 2015 to 2019
$2.3M
Microenvironment mediated drug resistance in melanoma.R01CA161107 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI SMALLEY, KEIRAN · 2011 to 2015
$1.7M
New therapeutic opportunities from mining polypharmacology mechanisms of ceritinib in ALK-negative non-small cell lung cancerF99CA212456 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KUENZI, BRENT · 2016 to 2017
$70k
NCI NIH HHS F99 CA212456NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA168536NCI NIH HHS R01 CA161107NCI NIH HHS R01 CA181746
6 · The paper itself

Abstract

Targeted therapy options are currently lacking for the heterogeneous population of patients whose melanomas lack

Indexed as

Antineoplastic AgentsCell Line, TumorHumansMelanomaProto-Oncogene Proteins B-rafPyridonesPyrimidinesPyrimidinonesSulfonesAntineoplastic AgentsceritinibProto-Oncogene Proteins B-rafPyridonesPyrimidinesPyrimidinonesSulfonestrametinib

Identifiers

PMID29133622
PMCPMC5752595
OpenAlexW2769267582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.