Evidence map›Paper›PMID 29133606›Full record

Trial reportCirculation2018

Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension).

Carlos Aurelio Schiavon, Angela Cristine Bersch-Ferreira, Eliana Vieira Santucci, Juliana Dantas Oliveira, Camila Ragne Torreglosa, Priscila Torres Bueno, Julia Caldas Frayha, Renato Nakagawa Santos, Lucas Petri Damiani, Patricia Malvina Noujaim and 11 more

Erratum issued 3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 141 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 8 pooled it
26.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01784848 nacompletednot on this map

Phase 3 Randomized Controlled Trial Evaluating the Effect of Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) on Hypertension Medication Reduction, Blood Pressure Levels and Others Cardiovascular Risk Factors.

TypeinterventionalSponsorHospital do CoracaoRan2013 to 2022Enrolled100ConditionsSystemic Hypertension, ObesityArmsLaparoscopic Roux-en-Y gastric bypass (LRYGB), Clinical treatment
NCT03975478 naunknown statusnot on this mapstarted 2019, after this paper: background citation

BASALTO (Bariatric Surgery and LDL Cholesterol) Trial

TypeinterventionalSponsorParc de Salut MarRan2019 to 2023Enrolled36ConditionsBariatric SurgeryArmsGastric bypass, Sleeve gastrectomy
NCT04626323 phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Open, Randomized, Unicenter Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease

TypeinterventionalSponsorHospital Alemão Oswaldo CruzRan2021 to 2024Enrolled60ConditionsDiabetes Mellitus, Type 2, Kidney Disease, Chronic, Kidney InjuryArmsRoux-en-Y gastric bypass, Best medical treatment
3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 8 syntheses or guidelines pooled it, 287 citations in OpenAlex.

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  8. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019
    Guideline
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81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Carlos Aurelio SchiavonResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.) cschiavon@hcor.com.br.
Angela Cristine Bersch-FerreiraResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Eliana Vieira SantucciResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Juliana Dantas OliveiraResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Camila Ragne TorreglosaResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Priscila Torres BuenoResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Julia Caldas FrayhaResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Renato Nakagawa SantosResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Lucas Petri DamianiResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Patricia Malvina NoujaimSurgical Center (P.M.N., H.H., F.L.J.M.).
Helio HalpernSurgical Center (P.M.N., H.H., F.L.J.M.).
Frederico L J MonteiroSurgical Center (P.M.N., H.H., F.L.J.M.).
Ricardo Vitor CohenOswaldo Cruz German Hospital, São Paulo, Brazil (R.V.C.).
Carlos H UchoaHeart Institute, Hypertension Unit, São Paulo, Brazil (C.H.U., L.B., L.F.D.).
Marcio Gonçalves de SouzaDepartment of Hypertension, Dante Pazzanese Institute of Cardiology, São Paulo, Brazil (M.G.d.S., C.A.).
Celso AmodeoDepartment of Hypertension, Dante Pazzanese Institute of Cardiology, São Paulo, Brazil (M.G.d.S., C.A.).
Luiz BortolottoHeart Institute, Hypertension Unit, São Paulo, Brazil (C.H.U., L.B., L.F.D.).
Dimas IkeokaIntensive Unit (D.I.), Heart Hospital, São Paulo, Brazil.
Luciano F DragerHeart Institute, Hypertension Unit, São Paulo, Brazil (C.H.U., L.B., L.F.D.).
Alexandre Biasi CavalcantiResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Otavio BerwangerResearch Institute (C.A.S., A.C.B.-F., E.V.S., J.D.O., C.R.T., P.T.B., J.C.F., R.N.F., L.P.D., A.B.C., O.B.).
Instituto Dante Pazzanese de Cardiologia · BRHospital São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent research efforts on bariatric surgery have focused on metabolic and diabetes mellitus resolution. Randomized trials designed to assess the impact of bariatric surgery in patients with obesity and hypertension are needed.

methodsIn this randomized, single-center, nonblinded trial, we included patients with hypertension (using ≥2 medications at maximum doses or >2 at moderate doses) and a body mass index between 30.0 and 39.9 kg/m

resultsWe included 100 patients (70% female, mean age 43.8±9.2 years, mean body mass index 36.9±2.7 kg/m2), and 96% completed follow-up. Reduction of ≥30% of the total number of antihypertensive medications while maintaining controlled blood pressure occurred in 41 of 49 patients from the gastric bypass group (83.7%) compared with 6 of 47 patients (12.8%) from the control group with a rate ratio of 6.6 (95% confidence interval, 3.1-14.0;

conclusionsBariatric surgery represents an effective strategy for blood pressure control in a broad population of patients with obesity and hypertension. CLINICAL

trial registrationURL: https://clinicaltrials.gov. Unique identifier: NCT01784848.

Indexed as

Blood PressureGastric BypassAdultAntihypertensive AgentsBody Mass IndexBrazilFemaleHumansHypertensionMaleMiddle AgedObesityTime FactorsTreatment OutcomeWeight LossAntihypertensive Agentsbariatric surgeryhypertensionobesity

Identifiers

PMID29133606
PMCPMC5865494
OpenAlexW2770989673

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.