Evidence map›Paper›PMID 29133564›Full record

ArticleAntimicrobial agents and chemotherapy2018

Fungal Prophylaxis with a Gastro-Resistant Posaconazole Tablet for Patients with Hematological Malignancies in the POSANANTES Study.

Pierre Peterlin, Cécile Chauvin, Steven Le Gouill, Morgane Pere, Marie Dalichampt, Thierry Guillaume, Alice Garnier, Maxime Paré, Amandine Le Bourgeois, Philippe Moreau and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Pierre PeterlinService d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nante, France pierre.peterlin@chu-nantes.fr.
Cécile ChauvinUnité de pharmacie clinique oncologique, Centre Hospitalier Universitaire de Nantes, CHU Hotel-Dieu, Nantes, France.
Steven Le GouillService d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nante, France.
Morgane PereDépartement Promotion de la Recherche Clinique, Centre Hospitalier Universitaire de Nantes, Nantes, France.
Marie DalichamptDépartement Promotion de la Recherche Clinique, Centre Hospitalier Universitaire de Nantes, Nantes, France.
Thierry GuillaumeService d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nante, France.
Alice GarnierService d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nante, France.
Maxime ParéService Pharmacie, Secteur essais cliniques, Centre Hospitalier Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nantes, France.
Amandine Le BourgeoisService d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nante, France.
Philippe MoreauService d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nante, France.
Patrice ChevallierService d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nante, France.
Guillaume DeslandesLaboratoire de Pharmacologie, Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nantes, France.
Thomas GastinneService d'Hématologie Clinique, Centre d'Investigation Clinique en Cancérologie (CI2C), Centre Hospitalier et Universitaire (CHU) de Nantes, CHU Hotel-Dieu, Nante, France.
Centre Hospitalier Universitaire de Nantes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Posaconazole is an antifungal drug used in both prophylaxis and treatment of invasive fungal infections. Its oral formulation requires therapeutic drug monitoring. To overcome gastric acidity, a gastro-resistant posaconazole tablet has recently been developed. POSANANTES was a prospective noninterventional study that aimed to monitor plasma concentration trough level (

Indexed as

AdultAgedAntibiotic ProphylaxisAntifungal AgentsFemaleFungiGraft vs Host DiseaseHematologic NeoplasmsHematopoietic Stem Cell TransplantationHumansInvasive Fungal InfectionsMaleMiddle AgedMultivariate AnalysisProspective StudiesStomachAntifungal AgentsposaconazoleTabletsTriazolesgastro-resistant tabletposaconazoleprophylaxis

Identifiers

PMID29133564
PMCPMC5786819
OpenAlexW2770881292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.