Evidence map›Paper›PMID 29133553›Full record

ArticleAntimicrobial agents and chemotherapy2018

Synthesis and Evaluation of Methyl 4-(7-Hydroxy-4,4,8-Trimethyl-3-Oxabicyclo[3.3.1]Nonan-2-yl)Benzoate as an Antileishmanial Agent and Its Synergistic Effect with Miltefosine.

Prachi Bhalla, Sabera Sultana, Adarsh Kumar Chiranjivi, Anil K Saikia, Vikash Kumar Dubey

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Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Prachi BhallaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India.
Sabera SultanaDepartment of Chemistry, Indian Institute of Technology Guwahati, Assam, India.
Adarsh Kumar ChiranjiviDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India.
Anil K SaikiaDepartment of Chemistry, Indian Institute of Technology Guwahati, Assam, India.
Vikash Kumar DubeyDepartment of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India vdubey@iitg.ernet.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our interest in oxabicyclic compounds as potent antileishmanial agents, the present work deals with the chemical synthesis of a new oxabicyclic derivative, methyl 4-(7-hydroxy-4,4,8-trimethyl-3-oxabicyclo[3.3.1]nonan-2-yl)benzoate (PS-207). This oxabicyclic derivative showed a good antileishmanial effect on the parasite, on both the promastigote and the amastigote. The mode of parasitic death from PS-207 seemed to be apoptosis-like. Interestingly, the combination of PS-207 with a low dose of miltefosine showed a synergistic effect against the parasite.

Indexed as

Antiprotozoal AgentsApoptosisBenzoatesCell Line, TumorHumansInhibitory Concentration 50Leishmania donovaniLeishmaniasis, VisceralPhosphorylcholineU937 CellsAntiprotozoal AgentsBenzoatesmiltefosinePhosphorylcholinedrug developmentLeishmania donovanimiltefosine

Identifiers

PMID29133553
PMCPMC5786811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.