ArticleCirculation. Cardiovascular quality and outcomes2017
Rheumatic Heart Disease Treatment Cascade in Uganda.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Circulation. Cardiovascular quality and outcomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Pooled it
- Preventive Interventions to Reduce the Burden of Rheumatic Heart Disease in Populations at Risk: A Systematic Review.Journal of the American Heart Association · 2024Pooled it
- Early Implementation and Clinical Outcomes of an Integrated Rheumatic Heart Disease Screening and Treatment Program in Northern Uganda.Circulation. Population health and outcomes · 2026Article
- Review
- Integrating secondary prevention of rheumatic heart disease into the primary healthcare system in Northern Uganda.BMJ global health · 2025Article
- Recent Advances on the Prevention and Management of Rheumatic Heart Disease.Global heart · 2025Review
- Intramuscular versus enteral penicillin prophylaxis to prevent progression of rheumatic heart disease: Study protocol for a noninferiority randomized trial (the GOALIE trial).American heart journal · 2024Article
- Socio-economic determinants influencing adherence to secondary prophylaxis in patients with rheumatic heart disease: a systematic review.Annals of medicine and surgery (2012) · 2024Review
- Outcomes and care quality metrics for people living with rheumatic heart disease and atrial fibrillation in Uganda.Heart rhythm O2 · 2024Article
- Adherence to penicillin treatment is essential for effective secondary prevention of rheumatic heart disease: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2024Review
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- A decentralized delivery program for rheumatic heart disease treatment and prevention in Uganda.Nature medicine · 2024Article
- Detection and management of latent rheumatic heart disease: a narrative review.Annals of medicine and surgery (2012) · 2023Review
- Article
- Development and User Testing of a Dynamic Tool for Rheumatic Heart Disease Management.Applied clinical informatics · 2023Article
- Tertiary prevention and treatment of rheumatic heart disease: a National Heart, Lung, and Blood Institute working group summary.BMJ global health · 2023Review
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- A Qualitative Study of Patients' Experiences, Enablers and Barriers of Rheumatic Heart Disease Care in Uganda.Global heart · 2023Article
- Clinical Profile and Outcomes of Rheumatic Heart Disease Patients Undergoing Surgical Valve Procedures in Uganda.Global heart · 2023Article
- Bridging community and clinic through digital health: Community-based adaptation of a mobile phone-based heart failure program for remote communities in Uganda.BMC digital health · 2023Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Chris T LongeneckerFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.) cxl473@case.edu.
Stephen R MorrisFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Twalib O AlikuFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Andrea BeatonFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Marco A CostaFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Moses R KamyaFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Cissy KityoFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Peter LwabiFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Grace MirembeFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Dorah NampijjaFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Joselyn RwebemberaFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Craig SableFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Robert A SalataFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Amy ScheelFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Daniel I SimonFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Isaac SsinabulyaFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Emmy OkelloFrom the Case Western Reserve University School of Medicine, Cleveland, OH (C.T.L., S.R.M., M.A.C., R.A.S., D.I.S.); Division of Cardiovascular Medicine (C.T.L., M.A.C., D.I.S.) and Department of Medicine, University Hospitals Cleveland Medical Center, OH (S.R.M., R.A.S.); Uganda Heart Institute, Kampala, Uganda (T.O.A., P.L., J.R., I.S., E.O.); Department of Pediatric Cardiology, Children's National Health System, Washington, DC (A.B., C.S., A.S.); Department of Medicine, Makerere University School of Medicine, Kampala, Uganda (M.R.K.); Joint Clinical Research Centre, Kampala, Uganda (C.K., G.M.); and Mbarara University of Science and Technology, Mbarara, Uganda (D.N.).
Uganda Management Institute · UGJoint Clinical Research Centre · UGCase Western Reserve University · USChildren's National · USMakerere University · UGMbarara University of Science and Technology · UG
Funding
Pericardial fat, inflammation, and structural heart disease in HIVK23HL123341 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI LONGENECKER, CHRIS TODD · 2014 to 2018
$885kNHLBI NIH HHS K23 HL123341NHLBI NIH HHS L30 HL115792
Abstract
backgroundRheumatic heart disease (RHD) is a leading cause of premature death and disability in low-income countries; however, few receive optimal benzathine penicillin G (BPG) therapy to prevent disease progression. We aimed to comprehensively describe the treatment cascade for RHD in Uganda to identify appropriate targets for intervention. METHODS AND
resultsUsing data from the Uganda RHD Registry (n=1504), we identified the proportion of patients in the following care categories: (1) diagnosed and alive as of June 1, 2016; (2) retained in care; (3) appropriately prescribed BPG; and (4) optimally adherent to BPG (>80% of prescribed doses). We used logistic regression to investigate factors associated with retention and optimal adherence. Overall, median (interquartile range) age was 23 (15-38) years, 69% were women, and 82% had clinical RHD. Median follow-up time was 2.4 (0.9-4.0) years. Retention in care was the most significant barrier to achieving optimal BPG adherence with only 56.9% (95% confidence interval, 54.1%-59.7%) of living subjects having attended clinic in the prior 56 weeks. Among those retained in care, however, we observed high rates of BPG prescription (91.6%; 95% confidence interval, 89.1%-93.5%) and optimal adherence (91.4%; 95% confidence interval, 88.7-93.5). Younger age, latent disease status, and access to care at a regional center were the strongest independent predictors of retention and optimal adherence.
conclusionsOur study suggests that improving retention in care-possibly by decentralizing RHD services-would have the greatest impact on uptake of antibiotic prophylaxis among patients with RHD in Uganda.
Indexed as
Disease ManagementRegistriesAdolescentAdultFemaleHumansMaleMorbidityPovertyPrognosisRetrospective StudiesRheumatic Heart DiseaseRisk AssessmentRisk FactorsUgandaYoung Adultadherencefollow-up studiesHIVhumanspovertyrheumatic heart disease
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