ArticleProceedings of the National Academy of Sciences of the United States of America2017
Intact hemisphere and corpus callosum compensate for visuomotor functions after early visual cortex damage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- White matter microstructure and its association with visuospatial processing development during early infancy.Scientific reports · 2026Article
- Pathways Mediating Blindsight After V1 Injury: A Systematic Review of Human and Monkey Studies.Basic and clinical neuroscience · 2025Review
- The role of the parahippocampal cortex in memory consolidation for scenes.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Analysis of Neuronal Excitability Profiles for Motor-Eloquent Brain Tumor Entities Using nTMS in 800 Patients.Cancers · 2025Article
- A preliminary study of white matter disconnections underlying deficits in praxis in left hemisphere stroke patients.Brain structure & function · 2024Article
- Review
- Role of corpus callosum in unconscious vision.Neuropsychologia · 2024Article
- Implicit Selective Attention: The Role of the Mesencephalic-basal Ganglia System.Current neuropharmacology · 2024Review
- Whole-brain, gray, and white matter time-locked functional signal changes with simple tasks and model-free analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Plasticity of callosal neurons in the contralesional cortex following traumatic brain injury.Neural regeneration research · 2023Article
- Degenerate pathway for processing smile and other emotional expressions in congenital facial palsy: an hdEEG investigation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Selective plasticity of callosal neurons in the adult contralesional cortex following murine traumatic brain injury.Nature communications · 2022Article
- Role of Structural, Metabolic, and Functional MRI in Monitoring Visual System Impairment and Recovery.Journal of magnetic resonance imaging : JMRI · 2021Review
- Human immunodeficiency virus-related decreases in corpus callosal integrity and corresponding increases in functional connectivity.Human brain mapping · 2021Article
- Oscillatory and structural signatures of language plasticity in brain tumor patients: A longitudinal study.Human brain mapping · 2021Article
- The posterior parietal cortex contributes to visuomotor processing for saccades in blindsight macaques.Communications biology · 2021Article
- Blue-Light Therapy Strengthens Resting-State Effective Connectivity within Default-Mode Network after Mild TBI.Journal of central nervous system disease · 2021Article
- Predicted disconnectome associated with progressive periventricular white matter ischemia.Cerebral circulation - cognition and behavior · 2021Article
- Review
- Changes in peri-calcarine cortical thickness in blindsight.Neuropsychologia · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Unilateral damage to the primary visual cortex (V1) leads to clinical blindness in the opposite visual hemifield, yet nonconscious ability to transform unseen visual input into motor output can be retained, a condition known as "blindsight." Here we combined psychophysics, functional magnetic resonance imaging, and tractography to investigate the functional and structural properties that enable the developing brain to partly overcome the effects of early V1 lesion in one blindsight patient. Visual stimuli appeared in either the intact or blind hemifield and simple responses were given with either the left or right hand, thereby creating conditions where visual input and motor output involve the same or opposite hemisphere. When the V1-damaged hemisphere was challenged by incoming visual stimuli, or controlled manual responses to these unseen stimuli, the corpus callosum (CC) dynamically recruited areas in the visual dorsal stream and premotor cortex of the intact hemisphere to compensate for altered visuomotor functions. These compensatory changes in functional brain activity were paralleled by increased connections in posterior regions of the CC, where fibers connecting homologous areas of the parietal cortex course.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.