Evidence map›Paper›PMID 29133349›Full record

ArticleInfection and immunity2018

Role of Calprotectin in Withholding Zinc and Copper from Candida albicans.

Angelique N Besold, Benjamin A Gilston, Jana N Radin, Christian Ramsoomair, Edward M Culbertson, Cissy X Li, Brendan P Cormack, Walter J Chazin, Thomas E Kehl-Fie, Valeria C Culotta

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. TheJournal of fungi (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Review
  9. The innate immune protein calprotectin ablates the bactericidal activity of β-lactam antibiotics.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Review
  11. CrpH ofFrontiers in microbiology · 2026
    Article
  12. The pathogenicity and future treatment strategies ofFrontiers in cellular and infection microbiology · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Calprotectin protectsmSystems · 2025
    Article
  17. Exploring metalloproteome remodeling in calprotectin-stressedbioRxiv : the preprint server for biology · 2025
    Article
  18. Review
  19. Review
  20. Review

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Angelique N BesoldDepartment of Biochemistry and Molecular Biology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Benjamin A GilstonDepartments of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, USA.
Jana N RadinDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Christian RamsoomairDepartments of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, USA.
Edward M CulbertsonDepartment of Biochemistry and Molecular Biology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Cissy X LiDepartment of Biochemistry and Molecular Biology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Brendan P CormackDepartment of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Walter J ChazinDepartments of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, USA.
Thomas E Kehl-FieDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Valeria C CulottaDepartment of Biochemistry and Molecular Biology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA vculott1@jhu.edu.
Johns Hopkins University · USVanderbilt University · USUniversity of Illinois Urbana-Champaign · US

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
Host-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2M
MOLECULAR BIOPHYSICS TRAINING PROGRAM AT VANDERBILTT32GM008320 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1989 to 2023
$7.9M
Copper as a nutrient for Candida albicans at the host-pathogen interfaceR01AI119949 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CULOTTA, VALERIA C · 2015 to 2019
$2.3M
Overcoming nutritional immunity: Staphylococcal adaptation to host-imposed manganese and zinc starvationR01AI118880 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KEHL-FIE, THOMAS EVERETT · 2016 to 2020
$1.9M
Kidney Cu Homeostasis and Ceruloplasmin during Infection and InflammationF31DK111114 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CULBERTSON, EDWARD MCLOUTH · 2016 to 2019
$177k
Calprotectin and metal withholding during Candida albicans invasion of the kidneyF32AI124506 · NIAID · JOHNS HOPKINS UNIVERSITY · PI BESOLD, ANGELIQUE NICOLE · 2016 to 2017
$114k
NCI NIH HHS T32 CA009110NIAID NIH HHS F32 AI124506NIAID NIH HHS R01 AI101171NIAID NIH HHS R01 AI118880NIAID NIH HHS R01 AI119949NIDDK NIH HHS F31 DK111114NIEHS NIH HHS T32 ES007028NIEHS NIH HHS T32 ES007141NIGMS NIH HHS T32 GM008320
6 · The paper itself

Abstract

The opportunistic fungal pathogen

Indexed as

AnimalsCandida albicansCopperFungal ProteinsHomeostasisLeukocyte L1 Antigen ComplexMiceMice, Inbred C57BLMice, KnockoutZincCopperFungal ProteinsLeukocyte L1 Antigen ComplexZinccalprotectinCandida albicanscoppernutritional immunityzinc

Identifiers

PMID29133349
PMCPMC5778358
OpenAlexW2768746771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.