Evidence map›Paper›PMID 29133328›Full record

ArticleBMJ open2017

Associations of time of day with cardiovascular disease risk factors measured in older men: results from the British Regional Heart Study.

Claudio Sartini, Peter H Whincup, S Goya Wannamethee, Barbara J Jefferis, Lucy Lennon, Gordon DO Lowe, Paul Welsh, Naveed Sattar, Richard W Morris

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Claudio SartiniDepartment of Primary Care & Population Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-1470-3212
Peter H WhincupPopulation Health Research Institute, St George's University of London, London, UK.
S Goya WannametheeDepartment of Primary Care & Population Health, University College London, London, UK.
Barbara J JefferisDepartment of Primary Care & Population Health, University College London, London, UK.
Lucy LennonDepartment of Primary Care & Population Health, University College London, London, UK.
Gordon DO LoweUniversity of Glasgow, Institute of Cardiovascular and Medical Sciences, Glasgow, UK.
Paul WelshUniversity of Glasgow, Institute of Cardiovascular and Medical Sciences, Glasgow, UK.
Naveed SattarUniversity of Glasgow, Institute of Cardiovascular and Medical Sciences, Glasgow, UK.
Richard W MorrisCentre for Academic Primary Care, Schoolof Social and Community Medicine, University of Bristol, Bristol, UK.

Funding

British Heart Foundation PG/09/024/26857British Heart Foundation RG/13/16/30528
6 · The paper itself

Abstract

objectiveWe estimated associations of time of day with cardiovascular disease (CVD) risk factors measured in older men.

methodsCVD risk factors (markers of inflammation and haemostasis, and cardiac markers) were measured on one occasion between 08:00 and 19:00 hours in 4252 men aged 60-79 years from the British Regional Heart Study. Linear models were used to estimate associations between time of day and risk factors. When an association was found, we examined whether the relationship between risk factors and cardiovascular mortality was affected by the adjustment for time of day using survival analyses.

resultsN-terminal pro-brain natriuretic peptide (NT-proBNP) levels increased by 3.3% per hour (95% CI 1.9% to 4.8%), interleukin-6 (IL-6) increased by 2.6% per hour (95% CI 1.8% to 3.4%), while tissue plasminogen activator (t-PA) decreased by 3.3% per hour (95% CI 3.7% to 2.9%); these associations were unaffected by adjustment for possible confounding factors. The percentages of variation in these risk factors attributable to time of day were less than 2%. In survival analyses, the association of IL-6, NT-proBNP and t-PA with cardiovascular mortality was not affected by the adjustment for time of day. C reactive protein, fibrinogen, D-dimer, von Willebrand factor and cardiac troponin T showed no associations with time of day.

conclusionsIn older men, markers of inflammation (IL-6), haemostasis (t-PA) and a cardiac marker (NT-proBNP) varied by time of day. The contribution of time of day to variations in these markers was small and did not appear to be relevant for the CVD risk prediction.

Indexed as

Time FactorsAgedBiomarkersCardiovascular DiseasesHumansInterleukin-6Linear ModelsMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsProspective StudiesRisk AssessmentRisk FactorsSurvival AnalysisTissue Plasminogen ActivatorBiomarkersIL6 protein, humanInterleukin-6Natriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Tissue Plasminogen ActivatorBiological MarkersCardiovascular DiseaseDiurnal VariationsOlder Adults

Identifiers

PMID29133328
PMCPMC5695475

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.