ArticlePhysiology & behavior2018
Distinct inflammatory response patterns are evident among men and women with higher depressive symptoms.
Article in Physiology & behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Acculturation and biological stress markers: A systematic review.Psychoneuroendocrinology · 2021Pooled it
- Disruptions of p11 (S100A10) and HPA Axis Homeostasis Participate in the Major Depressive Disorder (MDD) Especially in Female Patients.Neuropsychiatric disease and treatment · 2025Trial
- Mindfulness-based stress reduction increases stimulated IL-6 production among lonely older adults: A randomized controlled trial.Brain, behavior, and immunity · 2022Trial
- Biomarkers for response in major depression: comparing paroxetine and venlafaxine from two randomised placebo-controlled clinical studies.Translational psychiatry · 2019Trial
- Article
- Systemic inflammation and ex vivo inflammatory responses in first semester university students.Psychoneuroendocrinology · 2026Article
- Association Between Dietary Inflammatory Index and Depression Symptoms in Chronic Kidney Disease.Behavioural neurology · 2025Article
- Moving toward affective immunology: Legacy and future directions.Comprehensive psychoneuroendocrinology · 2024Article
- Higher IL-6 and IL-4 plasma levels in depressed elderly women are influenced by diabetes mellitus.Trends in psychiatry and psychotherapy · 2024Article
- The Problem of Malnutrition Associated with Major Depressive Disorder from a Sex-Gender Perspective.Nutrients · 2022Review
- Depressive symptoms and other negative psychological states relate to ex vivo inflammatory responses differently for men and women: Cross-sectional and longitudinal evidence.Physiology & behavior · 2022Article
- Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective.Frontiers in psychiatry · 2022Review
- Sex-specific regulation of IL-10 production in human adipose tissue in obesity.Frontiers in endocrinology · 2022Article
- Inflammation and future depressive symptoms among recently bereaved spouses.Psychoneuroendocrinology · 2021Article
- Sex differences in circulating inflammatory mediators as a function of substance use disorder.Drug and alcohol dependence · 2021Article
- The Association Between Loneliness and Inflammation: Findings From an Older Adult Sample.Frontiers in behavioral neuroscience · 2021Article
- Relationship satisfaction determines the association between Epstein-Barr virus latency and somatic symptoms after the loss of a spouse.Personal Relationships · 2020Article
- How was your day? Convergence of aggregated momentary and retrospective end-of-day affect ratings across the adult life span.Journal of personality and social psychology · 2020Article
- Positive and Negative Affect and Salivary Markers of Inflammation Among Young Adults.International journal of behavioral medicine · 2020Article
- Gender differences in the link between depressive symptoms andBrain, behavior, & immunity - health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Extensive research links depression and inflammation, with emerging evidence suggesting some differences between males and females in these associations. However, relatively few studies have examined stimulated inflammatory responses (ex vivo) in depression. The present research investigated the associations between depressive symptoms, basal inflammation, and LPS-stimulated production of pro- (IL-1β, IL-6, IL-8, TNF-α) and an anti-inflammatory cytokine (IL-10), with a focus on the extent to which gender moderates these relationships. As part of a larger study, 162 socio-economically and racially diverse subjects (ages 25-65, 67% women) completed extensive self-report measures, including depressive symptoms. Whole blood was quantified for basal inflammation, or incubated with 1μg/mL lipopolysaccharide (LPS) for 2h (at 37°C, 5% CO
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.