ArticleThe journal of allergy and clinical immunology. In practice
Longitudinal Evaluation of Chronic Rhinosinusitis Symptoms in a Population-Based Sample.
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Autoallergy in chronic rhinosinusitis and its clinical relevance.The World Allergy Organization journal · 2026Article
- Predictive Modeling of Surgically Recalcitrant Chronic Rhinosinusitis Using Integrated Feature Sets.Ear, nose, & throat journal · 2025Article
- Role of specific immunoglobulin-E in chronic rhinosinusitis: Its clinical relevance according to nasal challenge test.The World Allergy Organization journal · 2024Article
- Contemporary Trends in Frontal Sinus Balloon Sinuplasty: A Pilot Study.Spartan medical research journal · 2024Article
- Risk of new-onset and prevalent disease in chronic rhinosinusitis: A prospective cohort study.International forum of allergy & rhinology · 2023Article
- Sinonasal Biomarkers Defining Type 2-High and Type 2-Low Inflammation in Chronic Rhinosinusitis with Nasal Polyps.Journal of personalized medicine · 2022Article
- Use of endotypes, phenotypes, and inflammatory markers to guide treatment decisions in chronic rhinosinusitis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2020Review
- Radiologic sinus inflammation and symptoms of chronic rhinosinusitis in a population-based sample.Allergy · 2020Article
- A new approach to categorization of radiologic inflammation in chronic rhinosinusitis.PloS one · 2020Article
- Sinus Infections, Inflammation, and Asthma.Immunology and allergy clinics of North America · 2019Review
- Workplace Indirect Cost Impacts of Nasal and Sinus Symptoms and Related Conditions.Journal of occupational and environmental medicine · 2019Article
- Longitudinal evaluation of clustering of chronic sinonasal and related symptoms using exploratory factor analysis.Allergy · 2018Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundChronic rhinosinusitis (CRS) is a prevalent and disabling condition of the nose and sinuses. The natural history of CRS symptoms in a general population sample has not been previously studied.
objectiveIn a general population-based sample from Pennsylvania, we used 2 questionnaires mailed 6 months apart to estimate the prevalence of, and identify predictors for, stability or change in symptoms over time.
methodsWe mailed the baseline and 6-month follow-up questionnaires to 23,700 primary care patients and 7,801 baseline responders, respectively. We categorized nasal and sinus symptoms using European Position Paper on Rhinosinusitis (EPOS) epidemiologic criteria. We defined 6 symptom groups over time on the basis of the presence of CRS symptoms at baseline and follow-up. We performed multivariable survey logistic regression controlling for confounding variables comparing persistent versus nonpersistent, recurrent versus stable past, and incident versus never.
resultsThere were 4,966 responders at follow-up: 558 had persistent symptoms, 190 recurrent symptoms, and 83 new symptoms meeting EPOS criteria for CRS. The prevalence of persistent symptoms was 4.8% (95% CI, 3.8-5.8), whereas the annual cumulative incidence of new symptoms was 1.9% and of recurrent symptoms was 3.2%. More severe symptoms at baseline were associated with persistence, whereas minor symptoms, allergies, and multiple treatments were associated with the development of new symptoms.
conclusionsLess than half with nasal and sinus symptoms meeting CRS EPOS criteria in our general, regional population had symptom persistence over time, with symptom profiles at baseline and age of onset being strongly associated with stability of symptoms.
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