ArticleThe Journal of allergy and clinical immunology2018
Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9
Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 74 citations in OpenAlex.
- Selective Targeting of IL-1RAP-Dependent Eosinophilic Inflammation in Allergic Fungal Airway Disease.Allergy · 2026Article
- Innate airway immune response to fungal allergens.Frontiers in immunology · 2026Review
- The Pleiotropic IL-9 Network in Asthma Pathogenesis and Targeted Therapy.Journal of inflammation research · 2026Review
- Activation of TSLP-IL-9 Axis Hinders the Antifibrotic Effect of ST2 Deficiency in Pulmonary Fibrosis.International journal of molecular sciences · 2025Article
- TLR4Nature communications · 2025Article
- Stellate ganglion irradiation alleviates airway inflammation in asthmatic mice via activating SIRT1 signaling pathway.Scientific reports · 2025Article
- Regulatory mechanisms of Th9 cell differentiation.Frontiers in immunology · 2025Review
- Potential of alarmin-targeted bispecific and combination therapies in airway disease.Frontiers in allergy · 2025Review
- NRF2 is a spatiotemporal metabolic hub essential for the polyfunctionality of Th2 cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- TRPM2 exacerbates airway inflammation by regulating oxidized-CaMKⅡ in allergic asthma.Heliyon · 2024Article
- From the bench to the clinic: basophils and type 2 epithelial cytokines of thymic stromal lymphopoietin and IL-33.Clinical & translational immunology · 2024Review
- Angiotensin-(1-7) suppresses airway inflammation and airway remodeling via inhibiting ATG5 in allergic asthma.BMC pulmonary medicine · 2023Article
- Review
- L1 cell adhesion molecule may be a protective molecule for atrial fibrillation in patients with valvular heart disease.Heliyon · 2023Article
- Intestinal Microflora Altered by Vancomycin Exposure in Early Life Up-regulates Type 2 Innate Lymphocyte and Aggravates Airway Inflammation in Asthmatic Mice.Inflammation · 2023Article
- Aerosol physicochemical determinants of carbon black and ozone inhalation co-exposure induced pulmonary toxicity.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- NFκB1 inhibits memory formation and supports effector function of ILC2s in memory-driven asthma.Frontiers in immunology · 2023Article
- Review
- Stem Cell Therapy and Innate Lymphoid Cells.Stem cells international · 2022Review
- The Framework for Human Host Immune Responses to Four Types of Parasitic Infections and Relevant Key JAK/STAT Signaling.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundIL-33 plays an important role in the development of experimental asthma.
objectiveWe sought to study the role of the IL-33 receptor suppressor of tumorigenicity 2 (ST2) in the persistence of asthma in a mouse model.
methodsWe studied allergen-induced experimental asthma in ST2 knockout (KO) and wild-type control mice. We measured airway hyperresponsiveness by using flexiVent; inflammatory indices by using ELISA, histology, and real-time PCR; and type 2 innate lymphoid cells (ILC2s) in lung single-cell preparations by using flow cytometry.
resultsAirway hyperresponsiveness was increased in allergen-treated ST2 KO mice and comparable with that in allergen-treated wild-type control mice. Peribronchial and perivascular inflammation and mucus production were largely similar in both groups. Persistence of experimental asthma in ST2 KO mice was associated with an increase in levels of thymic stromal lymphopoietin (TSLP), IL-9, and IL-13, but not IL-5, in bronchoalveolar lavage fluid. Expectedly, ST2 deletion caused a reduction in IL-13
conclusionsGenetic deletion of the IL-33 receptor paradoxically increases TSLP production, which stimulates the emergence of IL-9
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.