Evidence map›Paper›PMID 29132947›Full record

Observational studyAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2018

Associations Between Weight Loss, Kidney Function Decline, and Risk of ESRD in the Chronic Kidney Disease in Children (CKiD) Cohort Study.

Elaine Ku, Joel D Kopple, Charles E McCulloch, Bradley A Warady, Susan L Furth, Robert H Mak, Barbara A Grimes, Mark Mitsnefes

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  3. Nutrition across the Entire Lifespan in CKD: From Childhood to Senescence.Clinical journal of the American Society of Nephrology : CJASN · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Elaine KuDivision of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA; Division of Pediatric Nephrology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA. Electronic address: elaine.ku@ucsf.edu.
Joel D KoppleLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, David Geffen of Medicine at UCLA and UCLA Fielding School of Public Health, Los Angeles, CA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Bradley A WaradyDivision of Pediatric Nephrology, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, MO.
Susan L FurthDivision of Pediatric Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Robert H MakDivision of Pediatric Nephrology, Department of Pediatrics, Rady Children's Hospital, La Jolla, CA.
Barbara A GrimesDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Mark MitsnefesDivision of Pediatric Nephrology, Department of Pediatrics, Cincinnati Children's Hospital, Cincinnati, OH.
University of California, San Francisco · USChildren's Hospital of Philadelphia · USChildren's Mercy Hospital · USCincinnati Children's Hospital Medical Center · USHarbor–UCLA Medical Center · USRady Children's Hospital-San Diego · US

Funding

Chronic Kidney Disease in Children Study (C-Kid)U01DK066174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SUSAN L. FURTH · 2003 to 2026
$25.1M
CKiD Cardiovascular Testing Travel SupplementU01DK066143 · NIDDK · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI Bradley Alan Warady · 2003 to 2026
$24.2M
The Kidney Disease in Children Data Management and Analysis Center (KIDMAC)U01DK066116 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MUNOZ, ALVARO · 2003 to 2017
$17.9M
Central Biochemistry Laboratory of the CKiD ConsortiumU01DK082194 · NIDDK · UNIVERSITY OF ROCHESTER · PI SCHWARTZ, GEORGE J · 2008 to 2017
$3.5M
Blood pressure trends, outcomes, and interventions in adolescents and young adults at increased cardiovascular riskK23HL131023 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KU, ELAINE · 2016 to 2020
$991k
Cardiovascular Disease in Children with Chronic Kidney DiseaseK24DK090070 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI MITSNEFES, MARK M. · 2011 to 2015
$839k
NHLBI NIH HHS K23 HL131023NIDDK NIH HHS K24 DK090070NIDDK NIH HHS U01 DK066116NIDDK NIH HHS U01 DK066143NIDDK NIH HHS U01 DK066174NIDDK NIH HHS U01 DK082194
6 · The paper itself

Abstract

backgroundAnorexia and malnutrition are associated with poor outcomes in children with chronic kidney disease (CKD). STUDY

designObservational cohort study. SETTING &

participantsWe assessed changes in body mass index (BMI) as kidney function declines and its association with risk for end-stage renal disease (ESRD) among 854 participants followed between 2005 to 2013 in the CKD in Children (CKiD) Study. PREDICTORS: Repeated measurements of estimated glomerular filtration rate (eGFR) by serum creatinine concentration in our trajectory analysis using mixed models; change in BMI z score (per year) after eGFR decreased to <35mL/min/1.73m OUTCOMES: Repeated measurements of BMI z score (as a reflection of weight status) in our trajectory analysis; ESRD in logistic regression models.

resultsDuring a mean longitudinal follow-up of 3.4 years, BMI z scores remained stable until eGFR decreased to <35mL/min/1.73m LIMITATIONS: Observational nature of our study, lack of longitudinal assessments of inflammatory markers.

conclusionsIn children and adolescents with CKD, weight loss mostly occurs when eGFR decreases to <35mL/min/1.73m

Indexed as

Body Mass IndexDisease ProgressionWeight LossAdolescentAge FactorsChildChild, PreschoolCohort StudiesFemaleGlomerular Filtration RateHumansKidney Failure, ChronicKidney Function TestsLinear ModelsMalePrognosisadolescentsBMI trajectoryBody mass index (BMI)childrenchronic kidney disease (CKD)CKD progressionend-stage renal disease (ESRD)growthheightmalnutritionpediatric CKDweight loss

Identifiers

PMID29132947
PMCPMC5916028
OpenAlexW2767784870

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.