Observational studyThe Journal of pediatrics2018
Bilirubin Albumin Binding and Unbound Unconjugated Hyperbilirubinemia in Premature Infants.
Observational study in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Determinants of unbound bilirubin and clinical utility of the total bilirubin/albumin ratio in neonates.Pediatric research · 2026Article
- Choline attenuates bilirubin induced effects on tyrosine phosphorylation and distribution in lipid rafts of L1 cell adhesion molecule in vivo.Pediatric research · 2026Article
- Factors Affecting the Relationship Between Total and Unbound Bilirubin in Preterm and Term Infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Unbound bilirubin and bilirubin-albumin binding levels of Japanese neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Sustained lower bilirubin-binding affinity of albumin in extremely preterm infants.Pediatric research · 2023Article
- Preoperative serum bilirubin is an independent prognostic factor for curatively resected esophageal squamous cell carcinoma.BMC cancer · 2023Article
- Impact of Protein Binding Capacity and Daily Dosage of a Drug on Total Serum Bilirubin Levels in Susceptible Infants.Children (Basel, Switzerland) · 2023Review
- Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage.Neuron · 2023Article
- Bilirubin inhibits lipid raft dependent functions of L1 cell adhesion molecule in rat pup cerebellar granule neurons.Pediatric research · 2021Article
- Choline supplementation prevents the effects of bilirubin on cerebellar-mediated behavior in choline-restricted Gunn rat pups.Pediatric research · 2021Article
- Bilirubin/albumin (B/A) ratios correlate with unbound bilirubin levels in preterm infants.Pediatric research · 2021Observational
- Review of bilirubin neurotoxicity I: molecular biology and neuropathology of disease.Pediatric research · 2020Review
- High unbound bilirubin for age: a neurotoxin with major effects on the developing brain.Pediatric research · 2019Review
- Developmental influence of unconjugated hyperbilirubinemia and neurobehavioral disorders.Pediatric research · 2019Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate the associations between unbound bilirubin (UB) and total serum bilirubin (TSB), bilirubin:albumin molar ratio (BAMR), and bilirubin albumin binding affinity (Ka) as a function of gestational age (GA) in infants born at 24-33 weeks GA. STUDY
designIn a prospective observational study, TSB and UB were measured twice daily at least 8 hours apart during the first postnatal week. Serum albumin was measured to calculate BAMR on each day. The highest UB on each day, corresponding TSB, and serum albumin were used to calculate the Ka on each day.
resultsFor the 166 infants studied, peak UB significantly correlated with concomitant Ka (r = -0.44, P = .001) but not with concomitant TSB or BAMR after adjusting for GA. On multiple regression analyses, there was a significant association of concomitant Ka (-0.06, 95% CI -0.08 to -0.04, P = .0001), but not concomitant TSB or BAMR with peak UB after controlling for GA, birth weight, race, and sex. GA group was a significant effect modifier for the association between Ka and peak UB (0.03, 95% CI 0.02-0.04, P < .001). Interaction analyses showed the association between concomitant Ka and peak UB was significant for the 24-30 weeks GA group infants, but not for the 30
conclusionsPeak UB was primarily associated with a decrease in binding affinity in infants ≤30 weeks GA. Interventions aimed at improving binding affinity may be important in decreasing the risk of bilirubin-induced neurotoxicity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.