Evidence map›Paper›PMID 29132568›Full record

ReviewSurgical oncology clinics of North America2018

Molecular Subtypes and Local-Regional Control of Breast Cancer.

Simona Maria Fragomeni, Andrew Sciallis, Jacqueline S Jeruss

Registry-linked trialAbstract readReview
In one paragraph

Review in Surgical oncology clinics of North America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05850637 (Phase II Study to Evaluate the Effectiveness and Toxicity of Adjuvant Ultra-hypofractionated Radiotherapy for the Treatment of Early and Locally Advanced Breast Cancer), which is not on this map. Cited by 226 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05850637 phase2completednot on this mapstarted 2019, after this paper: background citation

Phase II Study to Evaluate the Effectiveness and Toxicity of Adjuvant Ultra-hypofractionated Radiotherapy for the Treatment of Early and Locally Advanced Breast Cancer

TypeinterventionalSponsorPrevent Senior InstituteRan2019 to 2023Enrolled60ConditionsBreast Cancer FemaleArmsadjuvant ultra-hypofractionated radiotherapy
3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Survivin targeting triple-fusion vaccineMedical oncology (Northwood, London, England) · 2025
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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Simona Maria FragomeniDivision of Gynecologic Oncology, Multidisciplinary Breast Center, Catholic University of the Sacred Heart of Rome, L.go Agostino Gemelli 8, 00168 Rome, Italy.
Andrew SciallisDivision of Anatomic Pathology, Department of Pathology, University of Michigan, Ann Arbor, MI 48105, USA.
Jacqueline S JerussDivision of Anatomic Pathology, Department of Pathology, University of Michigan, Ann Arbor, MI 48105, USA; Division of Surgical Oncology, Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48105, USA. Electronic address: jjeruss@med.umich.edu.

Funding

Measuring signaling pathway dynamics during tissue growth in hydrogelsR01GM097220 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JERUSS, JACQUELINE SARA, SHEA, LONNIE D · 2012 to 2015
$1.4M
NIGMS NIH HHS R01 GM097220
6 · The paper itself

Abstract

In the era of personalized medicine, there has been significant progress regarding the molecular analysis of breast cancer subtypes. Research efforts have focused on how classification of subtypes could provide information on prognosis and influence treatment planning. Although much is known about the impact of different molecular subtypes on disease-specific survival, more recent studies have investigated the role of the different molecular subtypes on local-regional recurrence. This is an area of active study, and in recent years there has been significant progress. This article describes outcomes among disease subtypes to aid in optimal surgical decision-making to improve local-regional control.

Indexed as

Biomarkers, TumorBreast NeoplasmsFemaleGene Expression ProfilingHumansPrecision MedicineBiomarkers, TumorBreast cancerGene signaturesImmunohistochemical surrogatesLocal-regional recurrenceMolecular subtypes

Identifiers

PMID29132568
PMCPMC5715810

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.