ArticleMicrobiome2017
Identifying predictive features of Clostridium difficile infection recurrence before, during, and after primary antibiotic treatment.
Article in Microbiome, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04259931 (PROSPECTIVE STUDY OF PREDISPOSING FACTORS OF REFRACTARY Clostridium Difficile INFECTION. INFLUENCE OF THE GUT MICROBIOMA), which is not on this map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PROSPECTIVE STUDY OF PREDISPOSING FACTORS OF REFRACTARY Clostridium Difficile INFECTION. INFLUENCE OF THE GUT MICROBIOMA
Who cites it
23 citing papers in PubMed.
- A randomized controlled trial of precision bezlotoxumab treatment for Clostridioides difficile infection.Cell reports. Medicine · 2026Trial
- Personalized Clostridioides difficile colonization risk prediction and probiotic therapy assessment in the human gut.Cell systems · 2025Article
- The role of polysaccharides in immune regulation through gut microbiota: mechanisms and implications.Frontiers in immunology · 2025Review
- Gut Microbial and Metabolic Features Associated WithOpen forum infectious diseases · 2024Article
- Review
- Fecal microbiota composition is a better predictor of recurrent Clostridioides difficile infection than clinical factors in a prospective, multicentre cohort study.BMC infectious diseases · 2024Observational
- Island biogeography theory provides a plausible explanation for why larger vertebrates and taller humans have more diverse gut microbiomes.The ISME journal · 2024Article
- Evaluation of Gut Microbiota in Healthy Persons and Type 1 Diabetes Mellitus Patients in North-Western Russia.Microorganisms · 2023Article
- Microbiome profile and calprotectin levels as markers of risk of recurrentFrontiers in cellular and infection microbiology · 2023Article
- Review
- Inside out: Relations between the microbiome, nutrition, and eye health.Experimental eye research · 2022Review
- Gut Microbiota Composition Associated withPathogens (Basel, Switzerland) · 2022Review
- Gut metabolites predict Clostridioides difficile recurrence.Microbiome · 2022Article
- The microbial diversity following antibiotic treatment of Clostridioides difficile infection.BMC gastroenterology · 2021Article
- Temporal Gut Microbial Changes Predict Recurrent Clostridiodes Difficile Infection in Patients With and Without Ulcerative Colitis.Inflammatory bowel diseases · 2020Observational
- The Initial Gut Microbiota and Response to Antibiotic Perturbation Influence Clostridioides difficile Clearance in Mice.mSphere · 2020Article
- Article
- Defining Microbiome Health through a Host Lens.mSystems · 2019Article
- Antimicrobial Resistance in the Asia Pacific region: a meeting report.Antimicrobial resistance and infection control · 2019Article
- Dose Effects of Orally AdministeredFrontiers in cellular and infection microbiology · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColonization by the pathogen Clostridium difficile often occurs in the background of a disrupted microbial community. Identifying specific organisms conferring resistance to invasion by C. difficile is desirable because diagnostic and therapeutic strategies based on the human microbiota have the potential to provide more precision to the management and treatment of Clostridium difficile infection (CDI) and its recurrence.
methodsWe conducted a longitudinal study of adult patients diagnosed with their first CDI. We investigated the dynamics of the gut microbiota during antibiotic treatment, and we used microbial or demographic features at the time of diagnosis, or after treatment, to predict CDI recurrence. To check the validity of the predictions, a meta-analysis using a previously published dataset was performed.
resultsWe observed that patients' microbiota "before" antibiotic treatment was predictive of disease relapse, but surprisingly, post-antibiotic microbial community is indistinguishable between patients that recur or not. At the individual OTU level, we identified Veillonella dispar as a candidate organism for preventing CDI recurrence; however, we did not detect a corresponding signal in the conducted meta-analysis.
conclusionAlthough in our patient population, a candidate organism was identified for negatively predicting CDI recurrence, results suggest the need for larger cohort studies that include patients with diverse demographic characteristics to generalize species that robustly confer colonization resistance against C. difficile and accurately predict disease relapse.
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