ArticleBMC medical genetics2017
Association of NOS3 gene polymorphisms with essential hypertension in Sudanese patients: a case control study.
Article in BMC medical genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Association of endothelial nitric oxide synthase intron 4a/b gene polymorphisms and hypertension: a systematic review and meta-analysis.The Journal of international medical research · 2021Pooled it
- Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls.BMC cardiovascular disorders · 2021Pooled it
- Genetics of hypertension in populations affected by the Aral Sea ecological crisis: A case-control study.PloS one · 2026Article
- Review
- A comprehensive narrative review on precision medicine approach to hypertension: exploring the role of genetics, epigenetics, microbiome, and artificial intelligence.Journal of health, population, and nutrition · 2025Review
- Genomic Exploration of Essential Hypertension in African-Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family-Based Association Studies.Journal of the American Heart Association · 2025Article
- Endothelial cell-specific postnatal deletion of Nos3 preserves intraocular pressure homeostasis via macrophage recruitment and NOS2 upregulation.The Journal of clinical investigation · 2025Article
- Article
- Genetic Factors Contributing to the Pathogenesis of Essential Hypertension in Two African Populations.Journal of personalized medicine · 2024Article
- Article
- Genetic Polymorphisms of Endothelial Nitric Oxide Synthase Associated with Hypertension and Blood Homocysteine Levels.International journal of general medicine · 2024Article
- Genetic modulation of anemia severity, hemolysis level, and hospitalization rate in Angolan children with Sickle Cell Anemia.Molecular biology reports · 2022Article
- The Role of Single Nucleotide Variants ofBrain sciences · 2021Review
- Review
- The Role of Single-Nucleotide Variants ofMolecules (Basel, Switzerland) · 2021Review
- Genomic Association of Single Nucleotide Polymorphisms with Blood Pressure Response to Hydrochlorothiazide among South African Adults with Hypertension.Journal of personalized medicine · 2020Article
- The incidence of NOS3 gene polymorphisms on newborns with large and small birth weight.Molecular biology reports · 2020Article
- Association between endothelial nitric oxide synthase (NOS3) rs2070744 and the risk for migraine.The pharmacogenomics journal · 2020Article
- Beneficial effects of nicotinamide on hypertensive mice with impaired endothelial nitric oxide function.Journal of experimental nephrology · 2020Article
- Activation of the STAT1 Pathway Accelerates Periodontitis inJournal of dental research · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEssential hypertension (EH) is influenced by various environmental and genetic factors. Nitric oxide is important for the functional integrity of the vascular endothelium and is produced in endothelial cells by the enzyme endothelial nitric oxide synthase (eNOS). EH has a strong genetic component, and the NOS3 gene, which encodes eNOS, represents an interesting candidate for contribution to the phenotype. The most clinically relevant polymorphisms in the NOS3 gene are rs1799983 in exon 7 (encoding Glu298Asp), a variable number tandem repeat (VNTR) in intron 4, and rs2070744 (T-786C) in the promoter region. This study aims to investigate the association between these three polymorphisms in the NOS3 gene and EH in Sudanese patients.
methodsHypertensive patients (n = 157) > 18 years of age with established hypertension from various hospitals in Khartoum, and controls (n = 85) > 18 years of age and with blood pressure measurements <140/90, were included in this case control study. Genotypes at the NOS3 variants were determined using TaqMan and polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) analyses. Genotype and allele frequencies were compared between the two groups by χ
resultsThe rs2070744 polymorphism in NOS3 was found to be associated with EH in the Sudanese population as the patients group had higher frequency of CC genotype compared with the controls (6.6% vs 6.1%, p = 0.02). Considering a dominant inheritance model, the frequency of TC + CC genotypes in patients was significantly higher than that in the control subjects (52.6% vs 34.1%, respectively; p < 0.01), with an odds ratio (95% CI) of 2.14 (1.23-3.74). In addition, the C allele was more frequent in the patients than the control group (29.6% vs 20%, p = 0.03, OR = 1.84 (1.15-2.93)). The c allele of intron 4 VNTR was reported in >1% of the Sudanese population under study.
conclusionThe results of this study indicated that the rs2070744 polymorphism in NOS3 may be a genetic susceptibility factor for EH in the Sudanese population. The c allele of intron 4 VNTR is not rare in the Sudanese population.
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