ArticleBMC genomics2017
Genomic analysis of endemic clones of toxigenic and non-toxigenic Corynebacterium diphtheriae in Belarus during and after the major epidemic in 1990s.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 42 citations in OpenAlex.
- Life Identification Number (LIN) codes for the genomic taxonomy of Corynebacterium diphtheriae strains.Genome medicine · 2025Article
- Population structure and antimicrobial resistance ofMicrobial genomics · 2025Article
- Phylogenomic analyses of multidrug resistant Corynebacterium striatum strains isolated from patients in a tertiary care hospital in the UK.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Challenges of Diphtheria Toxin Detection.Toxins · 2024Review
- Genomic characterization of cocirculatingMicrobial genomics · 2023Article
- Genomic Epidemiology of Corynebacterium diphtheriae in New Caledonia.Microbiology spectrum · 2023Article
- A multiomic approach to defining the essential genome of the globally important pathogen Corynebacterium diphtheriae.PLoS genetics · 2023Article
- Genomic Analysis ofInternational journal of molecular sciences · 2023Article
- Multidrug-resistant toxigenicMicrobial genomics · 2023Article
- NewPathogens (Basel, Switzerland) · 2022Review
- Evidence of episodic positive selection inPeerJ · 2022Article
- Genomic Epidemiology and Strain Taxonomy ofJournal of clinical microbiology · 2021Article
- Phylogenomic Characterization of a NovelmSystems · 2021Article
- Spatiotemporal persistence of multiple, diverse clades and toxins of Corynebacterium diphtheriae.Nature communications · 2021Article
- Population genomics and antimicrobial resistance in Corynebacterium diphtheriae.Genome medicine · 2020Article
- Whole-Genome Sequencing of Corynebacterium diphtheriae Isolates Recovered from an Inner-City Population Demonstrates the Predominance of a Single Molecular Strain.Journal of clinical microbiology · 2020Article
- Phenotypic and Genotypic Correlates of Penicillin Susceptibility in Nontoxigenic Corynebacterium diphtheriae, British Columbia, Canada, 2015-2018.Emerging infectious diseases · 2020Article
- Genomic analysis of a novel nontoxigenicNew microbes and new infections · 2019Article
- Carriage of a Single Strain of NontoxigenicJournal of clinical microbiology · 2019Article
- Whole Genome Sequencing for Surveillance of Diphtheria in Low Incidence Settings.Frontiers in public health · 2019Review
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiphtheria remains a major public health concern with multiple recent outbreaks around the world. Moreover, invasive non-toxigenic strains have emerged globally causing severe infections. A diphtheria epidemic in the former Soviet Union in the 1990s resulted in ~5000 deaths. In this study, we analysed the genome sequences of a collection of 93 C. diphtheriae strains collected during and after this outbreak (1996 - 2014) in a former Soviet State, Belarus to understand the evolutionary dynamics and virulence capacities of these strains.
resultsC. diphtheriae strains from Belarus belong to ten sequence types (STs). Two major clones, non-toxigenic ST5 and toxigenic ST8, encompassed 76% of the isolates that are associated with sore throat and diphtheria in patients, respectively. Core genomic diversity is limited within outbreak-associated ST8 with relatively higher mutation rates (8.9 × 10
conclusionsNon-toxigenic C. diphtheriae ST5 and toxigenic ST8 strains have been endemic in Belarus both during and after the epidemic in 1990s. A high vaccine coverage has effectively controlled diphtheria in Belarus; however, non-toxigenic strains continue to circulate in the population. Recombination is an important evolutionary force in shaping the genomic diversity in C. diphtheriae. However, the relative role of recombination and mutations in diversification varies between different clones.
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