Evidence map›Paper›PMID 29132229›Full record

SynthesisJournal of neurotrauma2018

Hyperbaric Oxygen Therapy in the Treatment of Acute Severe Traumatic Brain Injury: A Systematic Review.

Samuel Daly, Maxwell Thorpe, Sarah Rockswold, Molly Hubbard, Thomas Bergman, Uzma Samadani, Gaylan Rockswold

Registry-linked trialAbstract readSystematic Review
In one paragraph

Synthesis in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06581003 (Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury), which is not on this map. Cited by 38 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 6 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06581003 phase3recruitingnot on this mapstarted 2024, after this paper: background citation

Hyperbaric Oxygen Treatment for Veterans With Traumatic Brain Injury

TypeinterventionalSponsorUniversity of South FloridaRan2024 to 2029Enrolled420ConditionsTraumatic Brain Injury, Military OperationsArmsOxygen 99.7 %, Oxygen 21 %
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 6 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Efficacy of rTMS combined with cognitive training in TBI with cognition disorder: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Review
  8. Oxygen therapy in the intensive care unit.Medical gas research · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Hyperoxia: Effective Mechanism of Hyperbaric Treatment at Mild-Pressure.International journal of molecular sciences · 2024
    Review
  17. Management Strategies Based on Multi-Modality Neuromonitoring in Severe Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Samuel Daly1 Department of Surgery, Hennepin County Medical Center , Minneapolis, Minnesota.
Maxwell Thorpe1 Department of Surgery, Hennepin County Medical Center , Minneapolis, Minnesota.
Sarah Rockswold3 Department of Physical Medicine and Rehabilitation, University of Minnesota , Minneapolis, Minnesota.
Molly Hubbard1 Department of Surgery, Hennepin County Medical Center , Minneapolis, Minnesota.
Thomas Bergman1 Department of Surgery, Hennepin County Medical Center , Minneapolis, Minnesota.
Uzma Samadani1 Department of Surgery, Hennepin County Medical Center , Minneapolis, Minnesota.
Gaylan Rockswold1 Department of Surgery, Hennepin County Medical Center , Minneapolis, Minnesota.
Hennepin County Medical Center · USUniversity of Minnesota · USUniversity of Minnesota Medical Center · US

Funding

Hyperbaric and Normobaric Oxygen in Severe Brain InjuryR01NS042126 · NINDS · MINNEAPOLIS MEDICAL RESEARCH FDN, INC. · PI ROCKSWOLD, GAYLAN L · 2003 to 2005
$1.2M
NINDS NIH HHS R01 NS042126
6 · The paper itself

Abstract

There has been no major advancement in a quarter of a century for the treatment of acute severe traumatic brain injury (TBI). This review summarizes 40 years of clinical and pre-clinical research on the treatment of acute TBI with hyperbaric oxygen therapy (HBO

Indexed as

Brain InjuriesBrain Injuries, TraumaticHumansHyperbaric OxygenationTreatment OutcomeGlasgow Coma ScaleGlasgow Outcome Scalehyperbaric oxygennormobaric hyperoxiatraumatic brain injury

Identifiers

PMID29132229
PMCPMC6909681
OpenAlexW2770678935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.