ArticlePLoS pathogens2017
GDSL lipases modulate immunity through lipid homeostasis in rice.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 188 citations in OpenAlex.
- A peach esterase/lipase mediates lipid remodeling as a protective mechanism against chilling injury.Plant physiology · 2026Article
- Transcriptomic Profiling Identifies Symbiosis-Induced GDSL Lipase Genes Associated with Soybean-Arbuscular Mycorrhizal Symbiosis.International journal of molecular sciences · 2026Article
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- Integration of GWAS and WGCNA reveals novel candidate genes for cottonseed oil content in Gossypium hirsutum L.BMC plant biology · 2026Article
- Evolutionary Expansion and Diversification of theBiology · 2026Article
- Lipid droplets at the interface of plant defense and pathogen exploitation.Frontiers in plant science · 2026Review
- A Novel Non-functional RFT1 Allele Delays Heading Date in Rice.Rice (New York, N.Y.) · 2025Article
- Haplotype shifts in the lipid-related OsGELP gene family underpin rice adaptation to high latitudes.Scientific reports · 2025Article
- Transcriptome analyses revealPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Transcriptome Analysis Reveals the Role ofBiomolecules · 2025Article
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A GDSL motif-containing lipase modulates Sclerotinia sclerotiorum resistance in Brassica napus.Plant physiology · 2024Article
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- A KNOX Ⅱ transcription factor suppresses the NLR immune receptor BRG8-mediated immunity in rice.Plant communications · 2024Article
- Dynamics of epitranscriptomes uncover translational reprogramming directed by ac4C in rice during pathogen infection.Nature plants · 2024Article
- Comparative transcriptome analysis reveals defense responses against soft rot induced by Pectobacterium aroidearum and Pectobacterium carotovorum in Pinellia ternata.BMC genomics · 2024Article
- OsGELP77, a QTL for broad-spectrum disease resistance and yield in rice, encodes a GDSL-type lipase.Plant biotechnology journal · 2024Article
- Identification of quantitative trait loci associated with leaf rust resistance in rye by precision mapping.BMC plant biology · 2024Article
- Proteomic profiling ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- OsGADD45a1: a multifaceted regulator of rice architecture, grain yield, and blast resistance.Plant cell reports · 2024Article
8 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipids and lipid metabolites play important roles in plant-microbe interactions. Despite the extensive studies of lipases in lipid homeostasis and seed oil biosynthesis, the involvement of lipases in plant immunity remains largely unknown. In particular, GDSL esterases/lipases, characterized by the conserved GDSL motif, are a subfamily of lipolytic enzymes with broad substrate specificity. Here, we functionally identified two GDSL lipases, OsGLIP1 and OsGLIP2, in rice immune responses. Expression of OsGLIP1 and OsGLIP2 was suppressed by pathogen infection and salicylic acid (SA) treatment. OsGLIP1 was mainly expressed in leaf and leaf sheath, while OsGLIP2 showed high expression in elongating internodes. Biochemical assay demonstrated that OsGLIP1 and OsGLIP2 are functional lipases that could hydrolyze lipid substrates. Simultaneous down-regulation of OsGLIP1 and OsGLIP2 increased plant resistance to both bacterial and fungal pathogens, whereas disease resistance in OsGLIP1 and OsGLIP2 overexpression plants was significantly compromised, suggesting that both genes act as negative regulators of disease resistance. OsGLIP1 and OsGLIP2 proteins mainly localize to lipid droplets and the endoplasmic reticulum (ER) membrane. The proper cellular localization of OsGLIP proteins is indispensable for their functions in immunity. Comprehensive lipid profiling analysis indicated that the alteration of OsGLIP gene expression was associated with substantial changes of the levels of lipid species including monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG). We show that MGDG and DGDG feeding could attenuate disease resistance. Taken together, our study indicates that OsGLIP1 and OsGLIP2 negatively regulate rice defense by modulating lipid metabolism, thus providing new insights into the function of lipids in plant immunity.
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