ArticlePloS one2017
High-throughput m6A-seq reveals RNA m6A methylation patterns in the chloroplast and mitochondria transcriptomes of Arabidopsis thaliana.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Who cites it
39 citing papers in PubMed, 61 citations in OpenAlex.
- Mitoepigenetic Targeting of Age-Related Dysfunction: Mechanisms, Therapeutic Avenues, and Transgenerational Implications.Aging advances · 2025Article
- The Roles of RNA Modifications in Regulating Chloroplast Performance and Photosynthesis Efficiency.International journal of molecular sciences · 2024Review
- m6A RNA methylation regulates mitochondrial function.Human molecular genetics · 2024Article
- Mitochondrial RNA maturation.RNA biology · 2024Review
- Detection, distribution, and functions of RNAFrontiers in plant science · 2024Review
- Integrating mitoepigenetics into research in mood disorders: a state-of-the-art review.Frontiers in physiology · 2024Review
- mScience advances · 2023Article
- Global hypermethylation of the N6-methyladenosine RNA modification associated with apple heterografting.Plant physiology · 2023Article
- The plant cytosolic mPlant communications · 2023Article
- Role of Epigenetic Factors in Response to Stress and Establishment of Somatic Memory of Stress Exposure in Plants.Plants (Basel, Switzerland) · 2023Review
- Coordination of mPlants (Basel, Switzerland) · 2023Article
- The emerging role of epitranscriptome in shaping stress responses in plants.Plant cell reports · 2023Review
- Article
- Plant organellar RNA maturation.The Plant cell · 2023Review
- Beyond transcription: compelling open questions in plant RNA biology.The Plant cell · 2023Article
- The role of epigenetic and epitranscriptomic modifications in plants exposed to non-essential metals.Frontiers in plant science · 2023Review
- The alteration of N6-methyladenosine (m6A) modification at the transcriptome-wide level in response of heat stress in bovine mammary epithelial cells.BMC genomics · 2022Article
- Epitranscriptomic mRNA modifications governing plant stress responses: underlying mechanism and potential application.Plant biotechnology journal · 2022Review
- Epitranscriptomics: An Additional Regulatory Layer in Plants' Development and Stress Response.Plants (Basel, Switzerland) · 2022Review
- Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
This study is the first to comprehensively characterize m6A patterns in the Arabidopsis chloroplast and mitochondria transcriptomes based on our open accessible data deposited in NCBI's Gene Expression Omnibus with GEO Series accession number of GSE72706. Over 86% of the transcripts were methylated by m6A in the two organelles. Over 550 and 350 m6A sites were mapped, with ~5.6 to ~5.8 and ~4.6 to ~4.9 m6A sites per transcript, to the chloroplast and mitochondria genome, respectively. The overall m6A methylation extent in the two organelles was greatly higher than that in the nucleus. The m6A motif sequences in the transcriptome of two organelles were similar to the nuclear motifs, suggesting that selection of the m6A motifs for RNA methylation was conserved between the nucleus and organelle transcriptomes. The m6A patterns of rRNAs and tRNAs in the organelle were similar to those in the nucleus. However, the m6A patterns in coding RNAs were distinct between the nucleus and the organelle, suggesting that that regulation of the m6A methylation patterns may be different between the nuclei and the organelles. The extensively methylated transcripts in the two organelles were mainly associated with rRNA, ribosomal proteins, photosystem reaction proteins, tRNA, NADH dehydrogenase and redox. On average, 64% and 79% of the transcripts in the two organelles showed differential m6A methylation across three organs of the leaves, flowers and roots. The m6A methylation extent in the chloroplast was higher than that in the mitochondria. This study provides deep insights into the m6A methylation topology and differentiation in the plant organelle transcriptomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.