ArticlePhysics in medicine and biology2018
The role of trapped bubbles in kidney stone detection with the color Doppler ultrasound twinkling artifact.
Article in Physics in medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Passive cavitation detection analysis of materials with varying levels of color Doppler twinkling.Ultrasonics · 2027Article
- The "snow globe" sign: a microvascular flow imaging artifact in cystic lesions, and the role of dispersed internal debris.Abdominal radiology (New York) · 2026Article
- Analysis of Color Doppler Twinkling on Breast Biopsy Markers With Hydrostatic Overpressurization and Micro-CT Imaging.Ultrasound in medicine & biology · 2026Article
- Acoustic Detection of Intracranial Cavitation Induced by Blunt Impacts in Polyacrylamide Human Head Models Across Varying Orientations.Annals of biomedical engineering · 2026Article
- Changes in bubble-cloud dissolution throughout the application of histotripsy pulses.Physical review applied · 2025Article
- Twinkling Peptide Nanoemulsions Enable Precision Ultrasound Detection of Atherosclerotic Plaques.Advanced functional materials · 2025Article
- Dynamics of crevice microbubbles that cause the twinkling artifact.Ultrasonics sonochemistry · 2024Article
- Using 3-D-Printed Structures to Evaluate the Potential Causes of the Color Doppler Twinkling Signature.Ultrasound in medicine & biology · 2024Article
- Twinkling-guided ultrasound detection of polymethyl methacrylate as a potential breast biopsy marker: a comparative investigation.European radiology experimental · 2022Article
- Renal Doppler Ultrasound in the Evaluation of Renal Function in Patients with Sepsis.Applied bionics and biomechanics · 2022Article
- Evidence of Microbubbles on Kidney Stones in Humans.Ultrasound in medicine & biology · 2020Article
- Detecting Kidney Stones Using Twinkling Artifacts: Survey of Kidney Stones with Varying Composition and Size.Ultrasound in medicine & biology · 2020Article
- For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy.Ultrasound in medicine & biology · 2019Review
- Innovations in Ultrasound Technology in the Management of Kidney Stones.The Urologic clinics of North America · 2019Review
- Review on Acoustic Droplet Vaporization in Ultrasound Diagnostics and Therapeutics.BioMed research international · 2019Review
- The influence of gas diffusion on bubble persistence in shock-scattering histotripsy.The Journal of the Acoustical Society of America · 2018Article
- Some Work on the Diagnosis and Management of Kidney Stones with Ultrasound.Acoustics today · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The color Doppler ultrasound twinkling artifact, which highlights kidney stones with rapidly changing color, has the potential to improve stone detection; however, its inconsistent appearance has limited its clinical utility. Recently, it was proposed stable crevice bubbles on the kidney stone surface cause twinkling; however, the hypothesis is not fully accepted because the bubbles have not been directly observed. In this paper, the micron or submicron-sized bubbles predicted by the crevice bubble hypothesis are enlarged in kidney stones of five primary compositions by exposure to acoustic rarefaction pulses or hypobaric static pressures in order to simultaneously capture their appearance by high-speed photography and ultrasound imaging. On filming stones that twinkle, consecutive rarefaction pulses from a lithotripter caused some bubbles to reproducibly grow from specific locations on the stone surface, suggesting the presence of pre-existing crevice bubbles. Hyperbaric and hypobaric static pressures were found to modify the twinkling artifact; however, the simple expectation that hyperbaric exposures reduce and hypobaric pressures increase twinkling by shrinking and enlarging bubbles, respectively, largely held for rough-surfaced stones but was inadequate for smoother stones. Twinkling was found to increase or decrease in response to elevated static pressure on smooth stones, perhaps because of the compression of internal voids. These results support the crevice bubble hypothesis of twinkling and suggest the kidney stone crevices that give rise to the twinkling phenomenon may be internal as well as external.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.