Observational studyAmerican journal of respiratory and critical care medicine2018
Increased Echocardiographic Pulmonary Pressure in HIV-infected and -uninfected Individuals in the Veterans Aging Cohort Study.
Observational study in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Pulmonary hypertension in the global population of adolescents and adults living with HIV: a systematic review and meta-analysis.Scientific reports · 2019Pooled it
- Echocardiography in HIV Disease.Current cardiology reports · 2026Review
- Cardiovascular diseases among people living with HIV/AIDS in Ethiopia: A scoping review.PloS one · 2026Article
- Global Landscape of Infection-Induced Pulmonary Hypertension.Infectious disease reports · 2025Review
- HIV-Tat and vascular endothelium: implications in the HIV associated brain, heart, and lung complications.Frontiers in immunology · 2025Review
- Self-reported cardiovascular disease risk factor screening among people living with HIV vs. members of the general population in Botswana: a community-based study.BMC public health · 2024Article
- HIV and Drug Use: A Tale of Synergy in Pulmonary Vascular Disease Development.Comprehensive Physiology · 2023Article
- Revised Definition of Pulmonary Hypertension and Approach to Management: A Clinical Primer.Journal of the American Heart Association · 2023Review
- Human Immunodeficiency Virus and Cardiac End-Organ Damage in Women: Findings From an Echocardiographic Study Across the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Longitudinal ECG changes among adults with HIV in Tanzania: A prospective cohort study.PLOS global public health · 2023Article
- HIV-associated Pulmonary Arterial Hypertension: A Report from the Pulmonary Hypertension Association Registry.American journal of respiratory and critical care medicine · 2022Article
- Mice with humanized immune system as novel models to study HIV-associated pulmonary hypertension.Frontiers in immunology · 2022Article
- Mildly elevated pulmonary artery systolic pressure on echocardiography: bridging the gap in current guidelines.The Lancet. Respiratory medicine · 2021Review
- HIV Infection and the Risk of World Health Organization-Defined Sudden Cardiac Death.Journal of the American Heart Association · 2021Observational
- Association between HIV and incident pulmonary hypertension in US Veterans: a retrospective cohort study.The lancet. Healthy longevity · 2021Article
- Impact of human immunodeficiency virus on pulmonary vascular disease.Global cardiology science & practice · 2021Review
- Associations Between HIV Serostatus and Cardiac Structure and Function Evaluated by 2-Dimensional Echocardiography in the Multicenter AIDS Cohort Study.Journal of the American Heart Association · 2021Observational
- HIV- and HCV-specific markers and echocardiographic pulmonary artery systolic pressure among United States veterans.Scientific reports · 2020Article
- Echocardiography in Patients with HIV Infection.Current cardiology reports · 2020Review
- Reply to TangAmerican journal of respiratory and critical care medicine · 2020Article
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Authors and funding
19 authors at 12 institutions in 1 country.
Funding
Abstract
rationaleThe epidemiology and prognostic impact of increased pulmonary pressure among HIV-infected individuals in the antiretroviral therapy era is not well described.
objectivesTo examine the prevalence, clinical features, and outcomes of increased echocardiographic pulmonary pressure in HIV-infected and -uninfected individuals.
methodsThis study evaluated 8,296 veterans referred for echocardiography with reported pulmonary artery systolic pressure (PASP) estimates from the Veterans Aging Cohort study, an observational cohort of HIV-infected and -uninfected veterans matched by age, sex, race/ethnicity, and clinical site. The primary outcome was adjusted mortality by HIV status. MEASUREMENTS AND MAIN
resultsPASP was reported in 2,831 HIV-infected and 5,465 HIV-uninfected veterans (follow-up [mean ± SD], 3.8 ± 2.6 yr). As compared with uninfected veterans, HIV-infected veterans with HIV viral load greater than 500 copies/ml (odds ratio, 1.27; 95% confidence interval [CI], 1.05-1.54) and those with CD4 cell count less than 200 cells/μl (odds ratio, 1.28; 95% CI, 1.02-1.60) had a higher prevalence of PASP greater than or equal to 40 mm Hg. As compared with uninfected veterans with a PASP less than 40 mm Hg, HIV-infected veterans with a PASP greater than or equal to 40 mm Hg had an increased risk of death (adjusted hazard ratio, 1.78; 95% CI, 1.57-2.01). This risk persisted even among participants without prevalent comorbidities (adjusted hazard ratio, 3.61; 95% CI, 2.17-6.01). The adjusted risk of mortality in HIV-infected veterans was higher at all PASP values than in uninfected veterans, including at values currently considered to be normal.
conclusionsHIV-infected people with high HIV viral loads or low CD4 cell counts have a higher prevalence of increased PASP than uninfected people. Mortality risk in HIV-infected veterans increases at lower values of PASP than previously recognized and is present even among those without prevalent comorbidities. These findings may inform clinical decision-making regarding screening and surveillance of pulmonary hypertension in HIV-infected individuals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.