ArticleBiomacromolecules2017
Cell Migration and Bone Formation from Mesenchymal Stem Cell Spheroids in Alginate Hydrogels Are Regulated by Adhesive Ligand Density.
Article in Biomacromolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
- Design Strategies to Target Joint Resident Mesenchymal Stem Cells for Osteochondral Regeneration.Cells · 2026Review
- Dynamic Tuning of MSC-Based Scaffolds for Neurological Protection After Brain or CNS Injury.Life (Basel, Switzerland) · 2026Review
- Modulating iMSC Spheroid Function with Mechanically Tunable Hydrogels to Strengthen the Bone-Muscle Axis.ACS biomaterials science & engineering · 2026Article
- Bone regeneration using adipose derived stem cell spheroids within 3D printed scaffolds in a rabbit radial defect model.Scientific reports · 2025Article
- Scaling Cultured Meat: Challenges and Solutions for Affordable Mass Production.Comprehensive reviews in food science and food safety · 2025Review
- Review
- Functionalized Annealed Microgels for Spatial Control of Osteogenic and Chondrogenic Differentiation.Advanced functional materials · 2024Article
- Mechanoregulation of MSC spheroid immunomodulation.APL bioengineering · 2024Article
- Skeletal Muscle Spheroids as Building Blocks for Engineered Muscle Tissue.ACS biomaterials science & engineering · 2024Article
- Low-Molecular-Weight PEGs for Cryopreservation of Stem Cell Spheroids.Biomaterials research · 2024Article
- Competitive Specific Anchorage of Molecules onto Surfaces: Quantitative Control of Grafting Densities and Contamination by Free Anchors.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Construction and Evaluation of Alginate Dialdehyde Grafted RGD Derivatives/Polyvinyl Alcohol/Cellulose Nanocrystals IPN Composite Hydrogels.Molecules (Basel, Switzerland) · 2023Article
- Engineered biomaterials to guide spheroid formation, function, and fabrication into 3D tissue constructs.Acta biomaterialia · 2023Review
- E7 Peptide Enables BMSC Adhesion and Promotes Chondrogenic Differentiation of BMSCs Via the LncRNA H19/miR675 Axis.Bioengineering (Basel, Switzerland) · 2023Article
- Hepatic Spheroid Formation on Carbohydrate-Functionalized Supramolecular Hydrogels.Biomacromolecules · 2023Article
- Recent Advances in Tissue-Engineered Cardiac Scaffolds-The Progress and Gap in Mimicking Native Myocardium Mechanical Behaviors.Journal of functional biomaterials · 2023Review
- Electroconductive agarose hydrogels modulate mesenchymal stromal cell adhesion and spreading through protein adsorption.Journal of biomedical materials research. Part A · 2023Article
- Hydrogel viscoelasticity modulates migration and fusion of mesenchymal stem cell spheroids.Bioengineering & translational medicine · 2023Article
- Structuring supramolecular hyaluronan hydrogels via peptide self-assembly for modulating the cell microenvironment.Materials today. Bio · 2023Article
- Simple Technique for Microscopic Evaluation of Active Cellular Invasion into 3D Hydrogel Constructs.ACS biomaterials science & engineering · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The adhesion and migration of cells entrapped in engineered materials is regulated by available adhesive ligands. Although mesenchymal stem cell (MSC) spheroids injected into damaged tissues promote repair, their transplantation in biomaterials which regulate cell migration from the aggregate may further enhance their therapeutic potential. Alginate hydrogels were modified with Arginine-Glycine-Aspartic acid (RGD) at increasing concentrations, and osteogenically induced human MSC spheroids were entrapped to assess cell migration, survival, and differentiation. Cell migration was greater from MSC spheroids in alginate modified with low RGD levels, while the osteogenic potential was higher for spheroids entrapped in unmodified or high RGD density gels in vitro. Upon ectopic implantation, microCT and immunohistochemistry revealed extensive osteogenesis in unmodified and high RGD density gels compared to low RGD density gels. These data suggest that restriction of MSC migration from spheroids correlates with enhanced spheroid osteogenic potential, representing a novel tool for bone tissue engineering.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.