ArticleNature medicine2017
UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis.
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Article in Nature medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 413 papers.
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413citing papers in PubMed
33.4field-weighted citation impact, top 1% of its field
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Who cites it
413 citing papers in PubMed, 641 citations in OpenAlex.
- Circulating succinate changes during acute cold exposure are not related with brown adipose tissue in humans.Journal of physiology and biochemistry · 2026Trial
- Long-term voluntary exercise partially reverses obesity-associated transcriptomic remodeling in brown adipose tissue.Metabolism open · 2026Article
- 6 weeks of fartlek-style endurance training does not alter physiological responses to mild cold exposure but attenuates the cold-induced plasma noradrenaline response: A randomized, matched control trial.Journal of clinical & translational endocrinology · 2026Article
- A futile NaNature metabolism · 2026Article
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- Brown fat protects against hepatic oxidative stress by remodeling the circulating metabolome.Cell metabolism · 2026Article
- Nicotinic Acetylcholine Receptor Signaling Activates Beige Adipocytes and Mediates Systemic Metabolism.Diabetes · 2026Article
- Integrative Genomic and Transcriptomic Insights into High-Altitude Adaptation in Changthangi Goats.Applied biochemistry and biotechnology · 2026Article
- The Adipose-Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte-Derived Neurotrophic Factor for WAT Browning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Orai1-mediated CaExperimental & molecular medicine · 2026Article
- The pro-tumorigenic functions of cancer-associated adipocytes are dependent on the mitochondrial chaperone tumor necrosis factor receptor-associated protein 1.Signal transduction and targeted therapy · 2026Article
- Identification of a human mitochondrial isoform of TRPV1: a thermostat regulating mitochondrial maximal temperature?Cellular and molecular life sciences : CMLS · 2026Article
- UCP1-Dependent Thermogenic Adipose Tissue in Human Disease: Adipose-Centered Mechanisms, Biomarker Limitations, and Translational Perspectives.International journal of molecular sciences · 2026Review
- Junctophilin-2-orchestrated calcium signalosome regulates brown adipocyte thermogenesis and energy metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers.Cell biochemistry and function · 2026Review
- Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Current obesity reports · 2026Review
- HuR-dependent expression of RyR2 contributes to calcium-mediated thermogenesis in murine brown adipocytes.Scientific reports · 2026Article
- Illuminating the metabolic sink: Optical probes for in vivo thermogenic fat imaging.Materials today. Bio · 2026Review
- Research progress in flap temperature monitoring technologies and applications after transplantation.APL bioengineering · 2026Review
- Enhanced metabolic benefits of dietary methionine restriction in cold resistant hybrid UCP1-deficient mice.The Journal of nutritional biochemistry · 2026Article
353 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 4 institutions in 2 countries.
Kenji IkedaDiabetes Center, University of California, San Francisco, San Francisco, California, USA.
Qianqian KangDiabetes Center, University of California, San Francisco, San Francisco, California, USA.
Takeshi YoneshiroDiabetes Center, University of California, San Francisco, San Francisco, California, USA.
Joao Paulo CamporezDepartments of Medicine and of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Hiroko MakiInstitute for Advanced Biosciences, Keio University, Yamagata, Japan.
Mayu HommaInstitute for Advanced Biosciences, Keio University, Yamagata, Japan.
Kosaku ShinodaDiabetes Center, University of California, San Francisco, San Francisco, California, USA.
Yong ChenDiabetes Center, University of California, San Francisco, San Francisco, California, USA.
Xiaodan LuDiabetes Center, University of California, San Francisco, San Francisco, California, USA.
Pema MaretichDiabetes Center, University of California, San Francisco, San Francisco, California, USA.
Kazuki TajimaDiabetes Center, University of California, San Francisco, San Francisco, California, USA.
Kolapo M AjuwonDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana, USA.
Tomoyoshi SogaInstitute for Advanced Biosciences, Keio University, Yamagata, Japan.
Shingo KajimuraDiabetes Center, University of California, San Francisco, San Francisco, California, USA.
University of California, San Francisco · USBroad Center · USKeio University · JPPurdue University West Lafayette · US
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRUMMEL, MATTHEW F · 2003 to 2019
$21.8MUCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MYale Mouse Metabolic Phenotyping CenterU24DK059635 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2001 to 2015
$8.9MMolecular mechanisms of UCP1-independent pathways in metabolic healthR01DK097441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Shingo Kajimura · 2012 to 2026
$5.9MMechanisms of Lipid-Induced Hepatic Insulin ResistanceR01DK040936 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 1989 to 2015
$5.1MBAT-mediated inter-organ communication in energy homeostasisR01DK108822 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAJIMURA, SHINGO · 2016 to 2019
$1.4MYale Mouse Metabolic Phenotyping CenterU2CDK059635 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2016 to 2016
$493kNIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK040936NIDDK NIH HHS R01 DK097441NIDDK NIH HHS R01 DK108822NIDDK NIH HHS U24 DK059635NIDDK NIH HHS U2C DK059635
Abstract
Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent thermogenic mechanism in beige fat that involves enhanced ATP-dependent Ca
Indexed as
Adipose Tissue, BeigeAnimalsAnimals, NewbornCalciumCalcium SignalingCells, CulturedGlucoseHEK293 CellsHomeostasisHumansMiceMice, Inbred C57BLMice, KnockoutSarcoplasmic Reticulum Calcium-Transporting ATPasesSignal TransductionSwineATP2A2 protein, humanAtp2a2 protein, mouseCalciumGlucoseSarcoplasmic Reticulum Calcium-Transporting ATPasesUcp1 protein, mouseUncoupling Protein 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.