ArticleCell adhesion & migration2018
Composite 3D printed scaffold with structured electrospun nanofibers promotes chondrocyte adhesion and infiltration.
Article in Cell adhesion & migration, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Evaluation of the Biological Response to Coating 3D-Printed PLA Scaffolds with Coaxial Gelatin-Based Electrospun Fibers.Biomimetics (Basel, Switzerland) · 2026Article
- Article
- Effects of thermomechanical parameters on surface texture in filament materials extrusion: outlook and trends.F1000Research · 2024Review
- The Effect of Polymeric Nanofibers Used for 3D-Printed Scaffolds on Cellular Activity in Tissue Engineering: A Review.International journal of molecular sciences · 2023Review
- Article
- Effect of electrohydrodynamic printing scaffold with different spacing on chondrocyte dedifferentiation.Annals of translational medicine · 2022Article
- Influence of surface topography on PCL electrospun scaffolds for liver tissue engineering.Journal of materials chemistry. B · 2021Article
- 3D Printable Electrically Conductive Hydrogel Scaffolds for Biomedical Applications: A Review.Polymers · 2021Review
- 3D Electrospun Nanofiber-Based Scaffolds: From Preparations and Properties to Tissue Regeneration Applications.Stem cells international · 2021Review
- A step toward engineering thick tissues: Distributing microfibers within 3D printed frames.Journal of biomedical materials research. Part A · 2020Article
- Strategies to Tune Electrospun Scaffold Porosity for Effective Cell Response in Tissue Engineering.Journal of functional biomaterials · 2019Review
- Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs.Materials today. Bio · 2019Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Additive manufacturing, also called 3D printing, is an effective method for preparing scaffolds with defined structure and porosity. The disadvantage of the technique is the excessive smoothness of the printed fibers, which does not support cell adhesion. In the present study, a 3D printed scaffold was combined with electrospun classic or structured nanofibers to promote cell adhesion. Structured nanofibers were used to improve the infiltration of cells into the scaffold. Electrospun layers were connected to 3D printed fibers by gluing, thus enabling the fabrication of scaffolds with unlimited thickness. The composite 3D printed/nanofibrous scaffolds were seeded with primary chondrocytes and tested in vitro for cell adhesion, proliferation and differentiation. The experiment showed excellent cell infiltration, viability, and good cell proliferation. On the other hand, partial chondrocyte dedifferentiation was shown. Other materials supporting chondrogenic differentiation will be investigated in future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.