Evidence map›Paper›PMID 29130824›Full record

ArticleNeurorehabilitation and neural repair2017

Longitudinal Structural and Functional Differences Between Proportional and Poor Motor Recovery After Stroke.

Adrian G Guggisberg, Pierre Nicolo, Leonardo G Cohen, Armin Schnider, Ethan R Buch

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurorehabilitation and neural repair, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.

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  5. Network-oriented neurorehabilitation after stroke: a paradigmatic approach.Journal of neuroengineering and rehabilitation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Adrian G Guggisberg1 Geneva University Hospital, Geneva, Switzerland.
Pierre Nicolo1 Geneva University Hospital, Geneva, Switzerland.
Leonardo G Cohen3 National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Armin Schnider1 Geneva University Hospital, Geneva, Switzerland.
Ethan R Buch3 National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
National Institute of Neurological Disorders and Stroke · USUniversity Hospital of Geneva · CHUniversity of Geneva · CH

Funding

Modulating brain plasticity in rehabilitation of stroke and other brain lesionsZIANS003030 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI COHEN, LEONARDO GREGORIO · 2009 to 2025
$23.2M
Intramural NIH HHS Z99 NS999999Swiss National Science Foundation 129679Swiss National Science Foundation 146639
6 · The paper itself

Abstract

backgroundEvolution of motor function during the first months after stroke is stereotypically bifurcated, consisting of either recovery to about 70% of maximum possible improvement ("proportional recovery, PROP") or in little to no improvement ("poor recovery, POOR"). There is currently no evidence that any rehabilitation treatment will prevent POOR and favor PROP.

objectiveTo perform a longitudinal and multimodal assessment of functional and structural changes in brain organization associated with PROP.

methodsFugl-Meyer Assessments of the upper extremity and high-density electroencephalography (EEG) were obtained from 63 patients, diffusion tensor imaging from 46 patients, at 2 and 4 weeks (T0) and at 3 months (T1) after stroke onset.

resultsWe confirmed the presence of 2 distinct recovery patterns (PROP and POOR) in our sample. At T0, PROP patients had greater integrity of the corticospinal tract (CST) and greater EEG functional connectivity (FC) between the affected hemisphere and rest of the brain, in particular between the ventral premotor and the primary motor cortex. POOR patients suffered from degradation of corticocortical and corticofugal fiber tracts in the affected hemisphere between T0 and T1, which was not observed in PROP patients. Better initial CST integrity correlated with greater initial global FC, which was in turn associated with less white matter degradation between T0 and T1.

conclusionsThese findings suggest links between initial CST integrity, systems-level cortical network plasticity, reduction of white matter atrophy, and clinical motor recovery after stroke. This identifies candidate treatment targets.

Indexed as

AdultAgedAged, 80 and overBrainDiffusion Tensor ImagingElectroencephalographyFemaleHumansLinear ModelsLongitudinal StudiesMaleMiddle AgedMotor ActivityMultivariate AnalysisPyramidal TractsRecovery of Functiondiffusion tensor imagingelectroencephalographymotor functionplasticitystroke

Identifiers

PMID29130824
PMCPMC6368856
OpenAlexW2770378830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.