Evidence map›Paper›PMID 29130647›Full record

Trial reportActa ophthalmologica2018

Randomized controlled trial of electro-stimulation therapies to modulate retinal blood flow and visual function in retinitis pigmentosa.

Ava K Bittner, Kenneth Seger, Rachel Salveson, Samantha Kayser, Natalia Morrison, Patricia Vargas, Deborah Mendelsohn, Jorge Han, Hua Bi, Gislin Dagnelie and 2 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta ophthalmologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02086890 (Modulating Ocular/Retinal Blood Flow and Visual Function in Retinitis Pigmentosa), which is not on this map. Cited by 30 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02086890 naactive not recruitingnot on this map

Modulating Ocular/Retinal Blood Flow and Visual Function in Retinitis Pigmentosa

TypeinterventionalSponsorNova Southeastern UniversityRan2014 to 2027Enrolled21ConditionsRetinitis PigmentosaArmsElectro-acupuncture, Laser Acupuncture, Transcorneal Electrical Stimulation, Sham Electro-acupuncture, Sham laser acupuncture
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  6. Longevity of visual improvements following transcorneal electrical stimulation and efficacy of retreatment in three individuals with retinitis pigmentosa.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Ava K BittnerCollege of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA.ORCID http://orcid.org/0000-0002-9498-2230
Kenneth SegerCollege of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA.
Rachel SalvesonCollege of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA.
Samantha KayserCollege of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA.
Natalia MorrisonHealing Blossom - Acupuncture and Holistic Medicine, Miami, FL, USA.
Patricia VargasMedical Sonography Program, College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
Deborah MendelsohnMedical Sonography Program, College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
Jorge HanMedical Sonography Program, College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
Hua BiCollege of Optometry, Nova Southeastern University, Fort Lauderdale, FL, USA.
Gislin DagnelieJohns Hopkins Wilmer Eye Institute, Baltimore, MD, USA.
Alexandra BenaventeSUNY College of Optometry, New York, NY, USA.
Jessica Ramella-RomanDepartment of Biomedical Engineering, Florida International University, Miami, FL, USA.
Nova Southeastern University · USFlorida International University · USJohns Hopkins University · USSUNY College of Optometry · US

Funding

Modulating Ocular/Retinal Blood Flow and Visual Function in Retinitis PigmentosaR21EY023720 · NEI · NOVA SOUTHEASTERN UNIVERSITY · PI BITTNER, AVA K · 2013 to 2013
$227k
NEI NIH HHS R21 EY023720
6 · The paper itself

Abstract

purposeWe examined changes in visual function and ocular and retinal blood flow (RBF) among retinitis pigmentosa (RP) participants in a randomized controlled trial of electro-stimulation therapies.

methodsTwenty-one RP participants were randomized (1:1:1) to transcorneal electrical stimulation (TES) at 6 weekly half-hour sessions, electro-acupuncture or inactive laser acupuncture (sham control) at 10 half-hour sessions over 2 weeks. Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity (VA), quick contrast sensitivity function, Goldmann visual fields, AdaptDx scotopic sensitivity, spectral flow and colour Doppler imaging of the central retinal artery (CRA), and RBF in macular capillaries were measured twice pre-treatment, after 2 TES sessions, within a week and a month after intervention completion.

resultsWe measured a significant improvement in retrobulbar CRA mean flow velocity for both the TES (p = 0.038) and electro-acupuncture groups (p = 0.001) on average after 2 weeks of treatment when compared to sham controls. Transcorneal electrical simulation (TES) and electro-acupuncture subjects had significant 55% and 34% greater increases, respectively, in RBF in the macular vessels when compared to sham controls (p < 0.001; p = 0.008) within a week of completing six TES sessions or a month after electro-acupuncture. There was a significant difference in the proportion of eyes that had improved visual function when comparing the three intervention groups (p = 0.038): four of seven TES subjects (57%), two of seven electro-acupuncture subjects (29%) and none of the seven control subjects (0%) had a significant visual improvement outside of typical test-retest variability at two consecutive post-treatment visits.

conclusionIncreased blood flow following electro-stimulation therapies is an objective, physiological change that occurred in addition to visual function improvements in some RP patients.

Indexed as

Contrast SensitivityAdultAgedCorneaElectric Stimulation TherapyElectroretinographyFemaleHumansMaleMiddle AgedRegional Blood FlowRetinal ArteryRetinitis PigmentosaTreatment OutcomeUltrasonography, Doppler, ColorVisual Acuityacupunctureretinal blood flowretinitis pigmentosatranscorneal electrical stimulation

Identifiers

PMID29130647
PMCPMC5920686
OpenAlexW2765822397

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.