Evidence map›Paper›PMID 29130333›Full record

ArticleAIDS care2018

Non-disclosure to male partners and incomplete PMTCT regimens associated with higher risk of mother-to-child HIV transmission: a national survey in Kenya.

Christine J McGrath, Benson Singa, Agnes Langat, John Kinuthia, Keshet Ronen, Danvers Omolo, Benjamin Elly Odongo, Rose Wafula, Prisca Muange, Abraham Katana and 2 more

Open access · greenAbstract read
In one paragraph

Article in AIDS care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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  18. Postpartum Depression and Prevention of Mother-to-Child Transmission of HIV in Kenya.The Journal of the Association of Nurses in AIDS Care : JANAC
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Christine J McGratha Department of Global Health , University of Washington , Seattle , WA , USA.
Benson Singab Centre for Clinical Research , Kenya Medical Research Institute , Nairobi , Kenya.
Agnes Langatc Division of Global HIV and TB , United States Centers for Disease Control and Prevention , Nairobi , Kenya.
John Kinuthiad Department of Obstetrics and Gynaecology , Kenyatta National Hospital , Nairobi , Kenya.
Keshet Ronene Fred Hutchinson Cancer Research Center , Seattle , WA , USA.
Danvers Omolob Centre for Clinical Research , Kenya Medical Research Institute , Nairobi , Kenya.
Benjamin Elly Odongoc Division of Global HIV and TB , United States Centers for Disease Control and Prevention , Nairobi , Kenya.
Rose Wafulaf Ministry of Health , National AIDS and STI Control Programme , Nairobi , Kenya.
Prisca Muangef Ministry of Health , National AIDS and STI Control Programme , Nairobi , Kenya.
Abraham Katanac Division of Global HIV and TB , United States Centers for Disease Control and Prevention , Nairobi , Kenya.
Lucy Ng'anga'c Division of Global HIV and TB , United States Centers for Disease Control and Prevention , Nairobi , Kenya.
Grace C John-Stewarta Department of Global Health , University of Washington , Seattle , WA , USA.
Centers for Disease Control and Prevention · KEKenya Medical Research Institute · KEMinistry of Health · KEUniversity of Washington · USFred Hutch Cancer Center · USKenyatta National Hospital · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Manoj P Menon · 1988 to 2026
$104.9M
PS09-991, KENYA, COPTIC HOSPITAL/UNIVERSITY OF WASHINGTON COLLABORATIVE HIV-1 CARE PROGRAMU2GPS002047 · PS · COPTIC ORTHODOX CHURCH · PI YOWAKIM, PAUL · 2010 to 2016
$27.7M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
UTMB WOMEN'S HEALTH RESEARCH SCHOLARS PROGRAMK12HD052023 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BERENSON, ABBEY B · 2005 to 2023
$8.1M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
NCHHSTP CDC HHS U2G PS002047NIAID NIH HHS P30 AI027757NIAID NIH HHS T32 AI007140NICHD NIH HHS K12 HD052023NICHD NIH HHS K24 HD054314PEPFAR
6 · The paper itself

Abstract

Health worker experience and community support may be higher in high HIV prevalence regions than low prevalence regions, leading to improved prevention of mother-to-child HIV transmission (PMTCT) programs. We evaluated 6-week and 9-month infant HIV transmission risk (TR) in a high prevalence region and nationally. Population-proportionate-to-size sampling was used to select 141 clinics in Kenya, and mobile teams surveyed mother-infant pairs attending 6-week and 9-month immunizations. HIV DNA testing was performed on HIV-exposed infants. Among 2521 mother-infant pairs surveyed nationally, 2423 (94.7%) reported HIV testing in pregnancy or prior diagnosis, of whom 200 (7.4%) were HIV-infected and 188 infants underwent HIV testing. TR was 8.8% (4.0%-18.3%) in 6-week and 8.9% (3.2%-22.2%) in 9-month cohorts including mothers with HIV diagnosed postpartum, of which 53% of infant infections were due to previously undiagnosed mothers. Of 276 HIV-exposed infants in the Nyanza survey, TR was 1.4% (0.4%-5.3%) at 6-week and 5.1% (2.5%-9.9%) at 9-months. Overall TR was lower in Nyanza, high HIV region, than nationally (3.3% vs. 7.2%, P = 0.02). HIV non-disclosure to male partners and incomplete ARVs were associated with TR in both surveys [aOR = 12.8 (3.0-54.3); aOR = 5.6 (1.2-27.4); aOR = 4.5 (1.0-20.0), aOR = 2.5, (0.8-8.4), respectively]. TR was lower in a high HIV prevalence region which had better ARV completion and partner HIV disclosure, possibly due to programmatic efficiencies or community/peer/partner support. Most 9-month infections were among infants of mothers without prior HIV diagnosis. Strategies to detect incident or undiagnosed maternal infections will be important to achieve PMTCT.

Indexed as

Self DisclosureAdultAIDS SerodiagnosisChildCross-Sectional StudiesFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalKenyaMaleMothersPregnancyPregnancy Complications, Infectiousantiretroviral therapydisclosurepediatricPrevention of mother-to-child transmission of HIVsurveillance

Identifiers

PMID29130333
PMCPMC5895526
OpenAlexW2767713801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.