Evidence map›Paper›PMID 29130272›Full record

ArticleHealth services research2017

Effects of Guideline and Formulary Changes on Statin Prescribing in the Veterans Affairs.

Adam A Markovitz, Rob G Holleman, Timothy P Hofer, Eve A Kerr, Mandi L Klamerus, Jeremy B Sussman

Open access · bronzeAbstract read
In one paragraph

Article in Health services research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. A Cost-Consequence Analysis of PreemptiveJournal of personalized medicine · 2021
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Adam A MarkovitzVA Center for Clinical Management and Research, Ann Arbor, MI.ORCID 0000-0002-4660-6978
Rob G HollemanVA Center for Clinical Management and Research, Ann Arbor, MI.
Timothy P HoferVA Center for Clinical Management and Research, Ann Arbor, MI.
Eve A KerrVA Center for Clinical Management and Research, Ann Arbor, MI.
Mandi L KlamerusVA Center for Clinical Management and Research, Ann Arbor, MI.
Jeremy B SussmanVA Center for Clinical Management and Research, Ann Arbor, MI.
University of Michigan · USVA Center for Clinical Management Research · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
HSRD VA IK2 HX001368NIDDK NIH HHS P30 DK092926NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

objectiveTo compare the effects of two sequential policy changes-the addition of a high-potency statin to the Department of Veterans Affairs (VA) formulary and the release of the American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines-on VA provider prescribing. DATA SOURCES/STUDY

settingRetrospective analysis of 1,100,682 VA patients, 2011-2016. STUDY

designInterrupted time-series analysis of changes in prescribing of moderate-to-high-intensity statins among high-risk patients and across high-risk subgroups. We also assessed changes in prescribing of atorvastatin and other statin drugs. We estimated marginal effects (ME) of formulary and guideline changes by comparing predicted and observed statin use. DATA COLLECTION/EXTRACTION

methodsData from VA Corporate Data Warehouse. PRINCIPAL

findingsThe use of moderate-to-high-intensity statins increased by 2 percentage points following the formulary change (ME, 2.4, 95% confidence interval [CI], 2.2 to 2.6) and less than 1 percentage point following the guideline change (ME, 0.8, 95% CI, 0.6 to 0.9). The formulary change led to approximately a 12 percentage-point increase in the use of moderate-to-high-intensity atorvastatin (ME, 11.5, 95% CI, 11.3 to 11.6). The relatively greater provider response to the formulary change occurred across all patient subgroups.

conclusionsAddition of a high-potency statin to formulary affected provider prescribing more than the ACC/AHA guidelines.

Indexed as

AdultAgedAmerican Heart AssociationDrug UtilizationFemaleFormularies, Hospital as TopicGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsInterrupted Time Series AnalysisMaleMiddle AgedPractice Guidelines as TopicPractice Patterns, Physicians'Retrospective StudiesRisk FactorsHydroxymethylglutaryl-CoA Reductase Inhibitorscardiovascular diseasepharmaceuticalsprovider interventionsquality of careVeterans Affairs

Identifiers

PMID29130272
PMCPMC5682154
OpenAlexW2768011977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.