Evidence map›Paper›PMID 29130177›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2018

Animal Models for Pseudomonas aeruginosa Quorum Sensing Studies.

Damien Maura, Arunava Bandyopadhaya, Laurence G Rahme

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Localized Infections withInternational journal of molecular sciences · 2023
    Article
  3. Article
  4. Chlorhexidine PromotesInternational journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Damien MauraDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Arunava BandyopadhayaDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Laurence G RahmeDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. rahme@molbio.mgh.harvard.edu.

Funding

Molecular and Metabolic inter-kingdom actions of a bacterial quorum sensing signal in promotion of host tolerance/resilience.R01AI134857 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2018 to 2022
$3.4M
Interruption of Signaling-Mediated Bacterial Persistent InfectionsR33AI105902 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2015 to 2017
$1.8M
Interruption of Signaling-Mediated Bacterial Persistent InfectionsR21AI105902 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI RAHME, LAURENCE G · 2013 to 2014
$478k
NIAID NIH HHS R01 AI134857NIAID NIH HHS R21 AI105902NIAID NIH HHS R33 AI105902
6 · The paper itself

Abstract

Quorum sensing (QS) systems play global regulatory roles in bacterial virulence. They synchronize the expression of multiple virulence factors and they control and modulate bacterial antibiotic tolerance systems and host defense mechanisms. Therefore, it is important to obtain knowledge about QS modes of action and to test putative therapeutics that may interrupt QS actions in the context of infections. This chapter describes methods to study bacterial pathogenesis in murine acute and persistent/relapsing infection models, using the Gram-negative bacterial pathogen Pseudomonas aeruginosa as an example. These infection models can be used to probe bacterial virulence functions and in mechanistic studies, as well as for the assessment of the therapeutic potential of antibacterials, including anti-virulence agents.

Indexed as

Quorum SensingAnimalsAnti-Bacterial AgentsBurnsDisease Models, AnimalLung DiseasesMaleMicePseudomonas aeruginosaPseudomonas InfectionsAnti-Bacterial AgentsAbdominal burn infectionAntibiotic toleranceBack burn infectionLung infectionOpen wound infectionPersistencePseudomonas aeruginosa

Identifiers

PMID29130177
PMCPMC6538071

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.