ArticleJACC. Clinical electrophysiology2017
The Electrophysiological Substrate of Early Repolarization Syndrome: Noninvasive Mapping in Patients.
Article in JACC. Clinical electrophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02647749 (Non-invasive Mapping of Rhythm Disorders), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-invasive Mapping of Rhythm Disorders
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2020Pooled it
- Prognostic Value of Spatial Trajectory of J-Point Amplitude Across Left Precordial Leads in a Community-Based Population.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Premature ventricular contraction-mediated ventricular fibrillation: Clinical characteristics, application of machine-learning algorithm, and outcomes of catheter ablation-A case series.Heart rhythm O2 · 2026Article
- Dynamic Echocardiographic Changes Induced by Exercise in Healthy, Young Individuals with Early Repolarization Pattern.Diagnostics (Basel, Switzerland) · 2025Article
- Electrophysiological Characterization of Subclinical and Overt Hypertrophic Cardiomyopathy by Magnetic Resonance Imaging-Guided Electrocardiography.Journal of the American College of Cardiology · 2024Article
- Technical development and feasibility of a reusable vest to integrate cardiovascular magnetic resonance with electrocardiographic imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Observational
- Radiofrequency catheter ablation of the left ventricular epicardium as an electrophysiological substrate in a patient with idiopathic ventricular fibrillation associated with early repolarization.HeartRhythm case reports · 2023Article
- Ventricular Conduction Stability Noninvasively Identifies an Arrhythmic Substrate in Survivors of Idiopathic Ventricular Fibrillation.Journal of the American Heart Association · 2023Article
- Cardiac Morphofunctional Characteristics of Individuals with Early Repolarization Pattern: A Literature Review.Journal of cardiovascular development and disease · 2022Review
- Steep repolarization time gradients in pig hearts cause distinct changes in composite electrocardiographic T-wave parameters.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022Article
- Contemporary Management of Complex Ventricular Arrhythmias.Arrhythmia & electrophysiology review · 2022Review
- Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar.Nature communications · 2022Article
- Distinct Features of Probands With Early Repolarization and Brugada Syndromes Carrying SCN5A Pathogenic Variants.Journal of the American College of Cardiology · 2021Article
- Noninvasive Mapping of Repolarization With Electrocardiographic Imaging.Journal of the American Heart Association · 2021Article
- Electrocardiographic Imaging of Repolarization Abnormalities.Journal of the American Heart Association · 2021Article
- Article
- In silico validation of electrocardiographic imaging to reconstruct the endocardial and epicardial repolarization pattern using the equivalent dipole layer source model.Medical & biological engineering & computing · 2020Article
- Spatial-Temporal Signals and Clinical Indices in Electrocardiographic Imaging (I): Preprocessing and Bipolar Potentials.Sensors (Basel, Switzerland) · 2020Article
- Spatial-Temporal Signals and Clinical Indices in Electrocardiographic Imaging (II): Electrogram Clustering and T-wave Alternans.Sensors (Basel, Switzerland) · 2020Article
- 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias.Heart rhythm · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Background: The early repolarization (ER) pattern is a common ECG finding. Recent studies established a definitive clinical association between ER and fatal ventricular arrhythmias. However, the arrhythmogenic substrate of ER in the intact human heart has not been characterized. Objectives: To map the epicardial electrophysiological (EP) substrate in ER syndrome patients using noninvasive Electrocardiographic Imaging (ECGI), and to characterize substrate properties that support arrhythmogenicity. Methods: Twenty-nine ER syndrome patients were enrolled, 17 of which had a malignant syndrome. Characteristics of the abnormal EP substrate were analyzed using data recorded during sinus rhythm. The EP mapping data were analyzed for electrogram morphology, conduction and repolarization. Seven normal subjects provided control data. Results: The abnormal EP substrate in ER syndrome patients has the following properties: (1) Abnormal epicardial electrograms characterized by presence of J-waves in localized regions; (2) Absence of conduction abnormalities, including delayed activation, conduction block, or fractionated electrograms; (3) Marked abbreviation of ventricular repolarization in areas with J-waves. The action potential duration (APD) was significantly shorter than normal (196±19 vs. 235±21 ms, p<0.05). Shortening of APD occurred heterogeneously, leading to steep repolarization gradients compared to normal control (45±17 vs.7±5 ms/cm, p<0.05). Premature ventricular contractions (PVCs) were recorded in 2 patients. The PVC sites of origin were closely related to the abnormal EP substrate with J-waves and steep repolarization gradients. Conclusions: Early Repolarization is associated with steep repolarization gradients caused by localized shortening of APD. Results suggest association of PVC initiation sites with areas of repolarization abnormalities. Conduction abnormalities were not observed.
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