Evidence map›Paper›PMID 29130055›Full record

ArticleTranslational perioperative and pain medicine2017

Gene therapy with HSV encoding p55TNFR gene for HIV neuropathic pain: an evidence-based mini-review.

Hirotsugu Kanda, Shue Liu, Megumi Kanao, Hyun Yi, Takafumi Iida, Wan Huang, Takayuki Kunisawa, David A Lubarsky, Shuanglin Hao

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Translational perioperative and pain medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hirotsugu KandaDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida 33136.
Shue LiuDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida 33136.
Megumi KanaoDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida 33136.
Hyun YiDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida 33136.
Takafumi IidaDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida 33136.
Wan HuangDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida 33136.
Takayuki KunisawaDepartment of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Japan 078-8510.
David A LubarskyDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida 33136.
Shuanglin HaoDepartment of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida 33136.
University of Miami · USAsahikawa Medical University · JP

Funding

Neuropathic mechanisms and gene therapy on opioid dependenceR01DA034749 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HAO, SHUANGLIN · 2014 to 2018
$1.7M
HIV and NRTI's-induced painful pathogenic mechanisms and gene therapyR01NS066792 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAO, SHUANGLIN · 2010 to 2014
$1.6M
Pathogenesis and Therapy of HIV-Related Neuropathic PainR21DA025527 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAO, SHUANGLIN · 2009 to 2010
$423k
Gene therapy of HIV-neuropathic pain with morphine toleranceR03DA026734 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HAO, SHUANGLIN · 2009 to 2010
$309k
NIDA NIH HHS R01 DA034749NIDA NIH HHS R03 DA026734NIDA NIH HHS R21 DA025527NINDS NIH HHS R01 NS066792
6 · The paper itself

Abstract

While effective antiretroviral treatment makes human immunodeficiency virus (HIV)-related death decreased dramatically, neuropathic pain becomes one of the most common complications in patients with HIV/acquired immunodeficiency syndrome (AIDS). The exact mechanisms of HIV-related neuropathic pain are not well understood yet, and no effective therapy is for HIV-pain. Evidence has shown that proinflammatory factors (e.g., tumor necrosis factor alpha (TNFα)) released from glia, are critical to contributing to chronic pain. Preclinical studies have demonstrated that non-replicating herpes simplex virus (HSV)-based vector expressing human enkephalin reduces inflammatory pain, neuropathic pain, or cancer pain in animal models. In this review, we describe recent advances in the use of HSV-based gene transfer for the treatment of HIV pain, with a special focus on the use of HSV-mediated soluble TNF receptor I (neutralizing TNFα in function) in HIV neuropathic pain model.

Indexed as

and gene therapyHIVneuropathic painsoluble TNF receptor

Identifiers

PMID29130055
PMCPMC5679115
OpenAlexW2804817565

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.