ArticleJournal of nucleic acids2017
Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis.
Article in Journal of nucleic acids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 5 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- The association of growth differentiation factor 5 rs143383 gene polymorphism with osteoarthritis: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Association of low-grade inflammation caused by gut microbiota disturbances with osteoarthritis: A systematic review.Frontiers in veterinary science · 2022Pooled it
- Correlation between growth differentiation factor 5 (rs143383) gene polymorphism and knee osteoarthritis: an updated systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- Association between the polymorphisms of CALM1 gene and osteoarthritis risk: a meta-analysis based on observational studies.Bioscience reports · 2018Pooled it
- The association between rs12885713 polymorphism in CALM1 and risk of osteoarthritis: A meta-analysis of case-control studies.Medicine · 2018Pooled it
- Biological Markers of Musculoskeletal Pain: A Scoping Review.Journal of pain research · 2024Article
- Computational Functional Genomics-Based AmpliSeq™ Panel for Next-Generation Sequencing of Key Genes of Pain.International journal of molecular sciences · 2021Article
- A novel variant near LSP1P3 is associated with knee osteoarthritis in the Chinese population.Clinical rheumatology · 2020Article
- Identifying the role of ASPN and COMP genes in knee osteoarthritis development.Journal of orthopaedic surgery and research · 2019Article
- Association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis: A systematic review and meta-analysis.Journal of orthopaedics · 2018Article
- Gender Differences in Osteoarthritis of Knee: An Indian Perspective.Journal of mid-life healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGenetic factors including the level of expression of the fingerprint of genes involved in the development of bones and cartilage such as GDF-5 or ESR-
methodsA case control study was carried out involving 500 patients of knee OA and equal number of healthy controls. Genotyping analyses in whole blood, mRNA, and protein expressions in peripheral blood lymphocytes (PBLs) were performed using established protocols.
resultsOur results showed a significantly decreased level of mRNA and protein expressions for GDF-5, ESR-
conclusionOur results demonstrated that the decrease in expression of GDF-5, ESR-
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.