Evidence map›Paper›PMID 29129987›Full record

ArticleOxidative medicine and cellular longevity2017

Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway.

Kim Vriens, Phalguni Tewari Kumar, Caroline Struyfs, Tanne L Cools, Pieter Spincemaille, Tadej Kokalj, Belém Sampaio-Marques, Paula Ludovico, Jeroen Lammertyn, Bruno P A Cammue and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Antifungals: From Pharmacokinetics to Clinical Practice.Antibiotics (Basel, Switzerland) · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. A Review: Antimicrobial Therapy for Human Pythiosis.Antibiotics (Basel, Switzerland) · 2022
    Review
  8. Article
  9. Membrane-Interacting Antifungal Peptides.Frontiers in cell and developmental biology · 2021
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Kim VriensCentre of Microbial and Plant Genetics, KU Leuven, 3001 Heverlee, Belgium.
Phalguni Tewari KumarBIOSYST-MEBIOS, KU Leuven, 3001 Heverlee, Belgium.
Caroline StruyfsCentre of Microbial and Plant Genetics, KU Leuven, 3001 Heverlee, Belgium.ORCID 0000-0003-3290-674X
Tanne L CoolsCentre of Microbial and Plant Genetics, KU Leuven, 3001 Heverlee, Belgium.
Pieter SpincemailleDepartment of Laboratory Medicine, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
Tadej KokaljBIOSYST-MEBIOS, KU Leuven, 3001 Heverlee, Belgium.
Belém Sampaio-MarquesLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.ORCID 0000-0001-6580-0971
Paula LudovicoLife and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.ORCID 0000-0003-4130-7167
Jeroen LammertynBIOSYST-MEBIOS, KU Leuven, 3001 Heverlee, Belgium.
Bruno P A CammueCentre of Microbial and Plant Genetics, KU Leuven, 3001 Heverlee, Belgium.ORCID 0000-0001-8087-4768
Karin ThevissenCentre of Microbial and Plant Genetics, KU Leuven, 3001 Heverlee, Belgium.ORCID 0000-0003-0275-9072
KU Leuven · BEIpca Laboratories (India) · INVIB-UGent Center for Plant Systems Biology · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amphotericin B (AmB) induces oxidative and nitrosative stresses, characterized by production of reactive oxygen and nitrogen species, in fungi. Yet, how these toxic species contribute to AmB-induced fungal cell death is unclear. We investigated the role of superoxide and nitric oxide radicals in AmB's fungicidal activity in

Indexed as

Amphotericin BAntifungal AgentsCandida albicansCandida glabrataNitric OxideSaccharomyces cerevisiaeAmphotericin BAntifungal AgentsNitric Oxide

Identifiers

PMID29129987
PMCPMC5654257
OpenAlexW2762354270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.