Evidence map›Paper›PMID 29129824›Full record

ArticleTurkish journal of haematology : official journal of Turkish Society of Haematology2018

Impact of Fluorescent In Situ Hybridization Aberrations and CLLU1 Expression on the Prognosis of Chronic Lymphocytic Leukemia: Presentation of 156 Patients from Turkey.

Ümmet Abur, Gönül Oğur, Ömer Salih Akar, Engin Altundağ, Huri Sema Aymelek, Düzgün Özatlı, Mehmet Turgut

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Turkish journal of haematology : official journal of Turkish Society of Haematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ümmet AburOndokuz Mayıs University Faculty of Medicine, Department of Medical Genetics, Samsun, Turkey.
Gönül OğurOndokuz Mayıs University Faculty of Medicine, Department of Medical Genetics, Samsun, Turkey.
Ömer Salih AkarOndokuz Mayıs University Faculty of Medicine, Department of Medical Genetics, Samsun, Turkey.
Engin AltundağOndokuz Mayıs University Faculty of Medicine, Department of Medical Genetics, Samsun, Turkey.
Huri Sema AymelekOndokuz Mayıs University Faculty of Medicine, Department of Medical Genetics, Samsun, Turkey.
Düzgün ÖzatlıOndokuz Mayıs University Faculty of Medicine, Department of Hematology, Samsun, Turkey.
Mehmet TurgutOndokuz Mayıs University Faculty of Medicine, Department of Hematology, Samsun, Turkey.
Ondokuz Mayıs University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study evaluates the impact of CLLU1 expression and fluorescent in situ hybridization (FISH) analysis of a group of Turkish chronic lymphocytic leukemia (CLL) patients. MATERIALS AND

methodsA total of 156 CLL patients were analyzed by FISH method; 47 of them were also evaluated for CLLU1 expression. Results were correlated with clinical parameters.

resultsFISH aberrations were found in 62% of patients. These aberrations were del13q14 (67%), trisomy 12 (27%), del11q22 (19%), del17p (8%), and 14q32 rearrangements (20%). Overall del11q22 and del17p were associated with the highest mortality rates, shortest overall survival (OS), and highest need for medication. Homozygous del13q14, 14q32 rearrangements, and higher CLLU1 expression correlated with shorter OS.

conclusionCytogenetics/FISH analysis is still indicated for routine evaluation of CLL. Special consideration is needed for the poor prognostic implications of del11q22, del17p, 14q32 rearrangements, and homozygous del13q14. The impact of CLLU1 expression is not yet clear and it requires more data before becoming routine in genetic testing in CLL patients.

Indexed as

Gene ExpressionAdultAgedAged, 80 and overBiomarkers, TumorChromosome AberrationsFemaleHumansIn Situ Hybridization, FluorescenceLeukemia, Lymphocytic, Chronic, B-CellMaleMiddle AgedNeoplasm ProteinsPrognosisRNA, Long NoncodingBiomarkers, TumorCLLU1 lncRNA, humanNeoplasm ProteinsRNA, Long NoncodingChronic leukemiaChronic lymphocytic leukemiaCytogenetics/FISH CLLU1.

Identifiers

PMID29129824
PMCPMC5843776
OpenAlexW2768307782

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.