Evidence map›Paper›PMID 29129796›Full record

ArticleProstaglandins & other lipid mediators2018

Comprehensive profiling of prostaglandins in human ovarian follicular fluid using mass spectrometry.

Bruce Pier, Johnathan W Edmonds, Landon Wilson, Alireza Arabshahi, Ray Moore, G Wright Bates, Jeevan K Prasain, Michael A Miller

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins & other lipid mediators, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Inflammatory and Redox Mediators in Rat and Human Ovulation.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bruce PierDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Alabama at Birmingham, United States.
Johnathan W EdmondsDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Alabama at Birmingham, United States.
Landon WilsonDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, United States.
Alireza ArabshahiDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, United States.
Ray MooreDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, United States.
G Wright BatesDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Alabama at Birmingham, United States.
Jeevan K PrasainDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, United States.
Michael A MillerDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, United States. Electronic address: mamiller@uab.edu.
University of Alabama at Birmingham · US

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
Prostaglandins in C. elegans FertilizationR01GM085105 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MILLER, MICHAEL A · 2008 to 2017
$2.8M
Acquired LTA4H Dysfunction in COPDR01HL110950 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2012 to 2015
$2.0M
PGP, A Possible Biomarker for COPD Exacerbations and or ProgressionR01HL114439 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BLALOCK, J EDWIN · 2012 to 2015
$1.5M
Genetic Regulation of Unconventional Prostaglandin MetabolismR01GM118361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PRASAIN, JEEVAN KUMAR, YODER, BRADLEY K. · 2016 to 2019
$1.2M
5500 Q-Trap Mass SpectrometerS10RR027822 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARNES, STEPHEN · 2010 to 2010
$469k
NCRR NIH HHS S10 RR027822NHLBI NIH HHS R01 HL110950NHLBI NIH HHS R01 HL114439NIDDK NIH HHS P30 DK079337NIGMS NIH HHS R01 GM085105NIGMS NIH HHS R01 GM118361
6 · The paper itself

Abstract

Prostaglandins are formed by enzymatic and non-enzymatic mechanisms. They have been detected in human ovarian follicular fluid (HFF), a medium rich in growth factors and nutrients important for oocyte growth and fertility. However, the comprehensive identification of HFF prostaglandins has not been addressed. Here we use hybrid triple quadrupole time-of-flight and triple quadrupole mass spectrometers to comprehensively analyze prostaglandins in HFF. We identified PGE1, PGE2, PGF2α, and other prostaglandins synthesized via prostaglandin-endoperoxide synthase (i.e. Cox) cascades. We also identified specific PGF2α isomers (F2-isoprostanes) and PGF3α analogs whose structures are inconsistent with Cox-dependent formation. A prospective cohort pilot study of infertility patient subtypes revealed two potential associations. F2-isoprostanes are decreased in the diminished ovarian reserve subtype and elevated PGF2α may be associated with decreased live birth. Other than PGF2α, only body mass index >25kg/m

Indexed as

Mass SpectrometryAdultFemaleFertilityFollicular FluidHumansLive BirthProstaglandinsProstaglandinsCyclooxygenaseFertilizationLipidMass spectrometryOvaryPolyunsaturated fatty acidProstaglandin

Identifiers

PMID29129796
PMCPMC5803327
OpenAlexW2767724520

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.