ArticleNeuroscience2018
The Interval Between VNS-Tone Pairings Determines the Extent of Cortical Map Plasticity.
Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Application of vagus nerve stimulation on the rehabilitation of upper limb dysfunction after stroke: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Autonomic nervous system dysfunction in irritable bowel syndrome: pathophysiology and therapeutic implications.Frontiers in neuroscience · 2026Review
- Characterization of an Algorithm for Autonomous, Closed-Loop Neuromodulation During Motor Rehabilitation.Neurorehabilitation and neural repair · 2024Article
- Vagus Nerve Stimulation (VNS) Modulates Synaptic Plasticity in the Infralimbic Cortex via Trk-B Receptor Activation to Reduce Drug-Seeking in Male Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Vagus nerve stimulation (VNS) modulates synaptic plasticity in the rat infralimbic cortex via Trk-B receptor activation to reduce drug-seeking.bioRxiv : the preprint server for biology · 2024Article
- Effective Delivery of Vagus Nerve Stimulation Requires Many Stimulations Per Session and Many Sessions Per Week Over Many Weeks to Improve Recovery of Somatosensation.Neurorehabilitation and neural repair · 2023Article
- Precise sound characteristics drive plasticity in the primary auditory cortex with VNS-sound pairing.Frontiers in neuroscience · 2023Article
- Efficacy profile of noninvasive vagus nerve stimulation on cortical spreading depression susceptibility and the tissue response in a rat model.The journal of headache and pain · 2022Article
- Common Cholinergic, Noradrenergic, and Serotonergic Drugs Do Not Block VNS-Mediated Plasticity.Frontiers in neuroscience · 2022Article
- A Review of Parameter Settings for Invasive and Non-invasive Vagus Nerve Stimulation (VNS) Applied in Neurological and Psychiatric Disorders.Frontiers in neuroscience · 2021Review
- The tactile experience paired with vagus nerve stimulation determines the degree of sensory recovery after chronic nerve damage.Behavioural brain research · 2021Article
- The impact of TMS and PNS frequencies on MEP potentiation in PAS with high-frequency peripheral component.PloS one · 2020Article
- Enhancing plasticity in central networks improves motor and sensory recovery after nerve damage.Nature communications · 2019Article
- Norepinephrine and serotonin are required for vagus nerve stimulation directed cortical plasticity.Experimental neurology · 2019Article
- Pairing vagus nerve stimulation with tones drives plasticity across the auditory pathway.Journal of neurophysiology · 2019Article
- Vagus Nerve Stimulation Rate and Duration Determine whether Sensory Pairing Produces Neural Plasticity.Neuroscience · 2019Article
- Protocol for Construction of Rat Nerve Stimulation Cuff Electrodes.Methods and protocols · 2019Article
- Targeted Vagus Nerve Stimulation for Rehabilitation After Stroke.Frontiers in neuroscience · 2019Review
- Varying Stimulation Parameters to Improve Cortical Plasticity Generated by VNS-tone Pairing.Neuroscience · 2018Article
- Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury.eLife · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Repeatedly pairing vagus nerve stimulation (VNS) with a tone or movement drives highly specific and long-lasting plasticity in auditory or motor cortex, respectively. Based on this robust enhancement of plasticity, VNS paired with rehabilitative training has emerged as a potential therapy to improve recovery, even when delivered long after the neurological insult. Development of VNS delivery paradigms that reduce therapy duration and maximize efficacy would facilitate clinical translation. The goal of the current study was to determine whether primary auditory cortex (A1) plasticity can be generated more quickly by shortening the interval between VNS-tone pairing events or by delivering fewer VNS-tone pairing events. While shortening the inter-stimulus interval between VNS-tone pairing events resulted in significant A1 plasticity, reducing the number of VNS-tone pairing events failed to alter A1 responses. Additionally, shortening the inter-stimulus interval between VNS-tone pairing events failed to normalize neural and behavioral responses following acoustic trauma. Extending the interval between VNS-tone pairing events yielded comparable A1 frequency map plasticity to the standard protocol, but did so without increasing neural excitability. These results indicate that the duration of the VNS-event pairing session is an important parameter that can be adjusted to optimize neural plasticity for different clinical needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.