ArticleCell metabolism2018
Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes.
Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 89 citations in OpenAlex.
- Trial
- Caloric restriction attenuates age-related liver and kidney alterations in mice: Histological evidence.Histology and histopathology · 2026Article
- Molecular mechanisms and pathogenesis of MASH.Nature · 2026Review
- Integrated analysis of insulin resistance reveals metabolic remodeling following diet switch-triggered calorie reduction.Science advances · 2026Article
- Impact of overweight and obesity on fasting insulin secretion in men and women without diabetes: effect sizes and mechanisms.Diabetologia · 2026Article
- The Pivotal Role of the Western Diet, Hyperinsulinemia, Ectopic Fat, and Diacylglycerol-Mediated Insulin Resistance in Type 2 Diabetes.International journal of molecular sciences · 2025Review
- Aetiology of type 2 diabetes: an experimental medicine odyssey.Diabetologia · 2025Review
- Preserving insulin function in diabetes: a case report.Journal of medical case reports · 2024Article
- Evaluating the evidence for a liver shrinkage diet for obese patients prior to laparoscopic cholecystectomy: A systematic review and meta-analysis.Journal of minimal access surgery · 2024Article
- A data-driven computational model for obesity-driven diabetes onset and remission through weight loss.iScience · 2023Article
- Review
- The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent.eLife · 2023Article
- Calorie restriction ameliorates hyperglycemia, modulates the disordered gut microbiota, and mitigates metabolic endotoxemia and inflammation in type 2 diabetic rats.Journal of endocrinological investigation · 2023Article
- Article
- Mitochondrial Stress in Metabolic Inflammation: Modest Benefits and Full Losses.Oxidative medicine and cellular longevity · 2022Review
- The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis.Nature communications · 2021Article
- Protective effects of calorie restriction on insulin resistance and islet function in STZ-induced type 2 diabetes rats.Nutrition & metabolism · 2021Article
- Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH.Molecular metabolism · 2021Review
- β-Cell Dysfunction, Hepatic Lipid Metabolism, and Cardiovascular Health in Type 2 Diabetes: New Directions of Research and Novel Therapeutic Strategies.Biomedicines · 2021Review
- Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation.JCI insight · 2021Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Caloric restriction rapidly reverses type 2 diabetes (T2D), but the mechanism(s) of this reversal are poorly understood. Here we show that 3 days of a very-low-calorie diet (VLCD, one-quarter their typical intake) lowered plasma glucose and insulin concentrations in a rat model of T2D without altering body weight. The lower plasma glucose was associated with a 30% reduction in hepatic glucose production resulting from suppression of both gluconeogenesis from pyruvate carboxylase (V
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Registered trials
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